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Page 1
An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma.
Davalos V, Lovell CD, Von Itter R, Dolgalev I, Agrawal P, Baptiste G, Kahler DJ, Sokolova E, Moran S, Piqué L, Vega-Saenz de Miera E, Fontanals-Cirera B, Karz A, Tsirigos A, Yun C, Darvishian F, Etchevers HC, Osman I, Esteller M, Schober M, Hernando E. Davalos V, et al. Among authors: karz a. Nat Commun. 2023 Apr 4;14(1):1867. doi: 10.1038/s41467-023-36967-2. Nat Commun. 2023. PMID: 37015919 Free PMC article.
Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis.
Hanniford D, Ulloa-Morales A, Karz A, Berzoti-Coelho MG, Moubarak RS, Sánchez-Sendra B, Kloetgen A, Davalos V, Imig J, Wu P, Vasudevaraja V, Argibay D, Lilja K, Tabaglio T, Monteagudo C, Guccione E, Tsirigos A, Osman I, Aifantis I, Hernando E. Hanniford D, et al. Among authors: karz a. Cancer Cell. 2020 Jan 13;37(1):55-70.e15. doi: 10.1016/j.ccell.2019.12.007. Cancer Cell. 2020. PMID: 31935372 Free PMC article.
The histone demethylase PHF8 regulates TGFβ signaling and promotes melanoma metastasis.
Moubarak RS, de Pablos-Aragoneses A, Ortiz-Barahona V, Gong Y, Gowen M, Dolgalev I, Shadaloey SAA, Argibay D, Karz A, Von Itter R, Vega-Sáenz de Miera EC, Sokolova E, Darvishian F, Tsirigos A, Osman I, Hernando E. Moubarak RS, et al. Among authors: karz a. Sci Adv. 2022 Feb 18;8(7):eabi7127. doi: 10.1126/sciadv.abi7127. Epub 2022 Feb 18. Sci Adv. 2022. PMID: 35179962 Free PMC article.
Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis.
Kleffman K, Levinson G, Rose IVL, Blumenberg LM, Shadaloey SAA, Dhabaria A, Wong E, Galán-Echevarría F, Karz A, Argibay D, Von Itter R, Floristán A, Baptiste G, Eskow NM, Tranos JA, Chen J, Vega Y Saenz de Miera EC, Call M, Rogers R, Jour G, Wadghiri YZ, Osman I, Li YM, Mathews P, DeMattos RB, Ueberheide B, Ruggles KV, Liddelow SA, Schneider RJ, Hernando E. Kleffman K, et al. Among authors: karz a. Cancer Discov. 2022 May 2;12(5):1314-1335. doi: 10.1158/2159-8290.CD-21-1006. Cancer Discov. 2022. PMID: 35262173 Free PMC article.
Dissecting the treatment-naive ecosystem of human melanoma brain metastasis.
Biermann J, Melms JC, Amin AD, Wang Y, Caprio LA, Karz A, Tagore S, Barrera I, Ibarra-Arellano MA, Andreatta M, Fullerton BT, Gretarsson KH, Sahu V, Mangipudy VS, Nguyen TTT, Nair A, Rogava M, Ho P, Koch PD, Banu M, Humala N, Mahajan A, Walsh ZH, Shah SB, Vaccaro DH, Caldwell B, Mu M, Wünnemann F, Chazotte M, Berhe S, Luoma AM, Driver J, Ingham M, Khan SA, Rapisuwon S, Slingluff CL Jr, Eigentler T, Röcken M, Carvajal R, Atkins MB, Davies MA, Agustinus A, Bakhoum SF, Azizi E, Siegelin M, Lu C, Carmona SJ, Hibshoosh H, Ribas A, Canoll P, Bruce JN, Bi WL, Agrawal P, Schapiro D, Hernando E, Macosko EZ, Chen F, Schwartz GK, Izar B. Biermann J, et al. Among authors: karz a. Cell. 2022 Jul 7;185(14):2591-2608.e30. doi: 10.1016/j.cell.2022.06.007. Cell. 2022. PMID: 35803246 Free PMC article.
Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities.
Karz A, Dimitrova M, Kleffman K, Alvarez-Breckenridge C, Atkins MB, Boire A, Bosenberg M, Brastianos P, Cahill DP, Chen Q, Ferguson S, Forsyth P, Glitza Oliva IC, Goldberg SB, Holmen SL, Knisely JPS, Merlino G, Nguyen DX, Pacold ME, Perez-Guijarro E, Smalley KSM, Tawbi HA, Wen PY, Davies MA, Kluger HM, Mehnert JM, Hernando E. Karz A, et al. Pigment Cell Melanoma Res. 2022 Nov;35(6):554-572. doi: 10.1111/pcmr.13059. Epub 2022 Sep 1. Pigment Cell Melanoma Res. 2022. PMID: 35912544 Free PMC article. Review.
MetFinder: A Tool for Automated Quantitation of Metastatic Burden in Histological Sections From Preclinical Models.
Karz A, Coudray N, Bayraktar E, Galbraith K, Jour G, Shadaloey AAS, Eskow N, Rubanov A, Navarro M, Moubarak R, Baptiste G, Levinson G, Mezzano V, Alu M, Loomis C, Lima D, Rubens A, Jilaveanu L, Tsirigos A, Hernando E. Karz A, et al. Pigment Cell Melanoma Res. 2024 Sep 10. doi: 10.1111/pcmr.13195. Online ahead of print. Pigment Cell Melanoma Res. 2024. PMID: 39254030
HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness.
Ho JS, Di Tullio F, Schwarz M, Low D, Incarnato D, Gay F, Tabaglio T, Zhang J, Wollmann H, Chen L, An O, Chan THM, Hall Hickman A, Zheng S, Roudko V, Chen S, Karz A, Ahmed M, He HH, Greenbaum BD, Oliviero S, Serresi M, Gargiulo G, Mann KM, Hernando E, Mulholland D, Marazzi I, Wee DKB, Guccione E. Ho JS, et al. Among authors: karz a. Elife. 2021 Jun 2;10:e59654. doi: 10.7554/eLife.59654. Elife. 2021. PMID: 34075878 Free PMC article.
Unveiling Common Transcriptomic Features between Melanoma Brain Metastases and Neurodegenerative Diseases.
Soler-Sáez I, Karz A, Hidalgo MR, Gómez-Cabañes B, López-Cerdán A, Català-Senent JF, Prutisto-Chang K, Eskow NM, Izar B, Redmer T, Kumar S, Davies MA, de la Iglesia-Vayá M, Hernando E, García-García F. Soler-Sáez I, et al. Among authors: karz a. J Invest Dermatol. 2024 Sep 24:S0022-202X(24)02149-3. doi: 10.1016/j.jid.2024.09.005. Online ahead of print. J Invest Dermatol. 2024. PMID: 39326662
16 results