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Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation.
Beck DB, Basar MA, Asmar AJ, Thompson JJ, Oda H, Uehara DT, Saida K, Pajusalu S, Talvik I, D'Souza P, Bodurtha J, Mu W, Barañano KW, Miyake N, Wang R, Kempers M, Tamada T, Nishimura Y, Okada S, Kosho T, Dale R, Mitra A, Macnamara E; Undiagnosed Diseases Network; Matsumoto N, Inazawa J, Walkiewicz M, Õunap K, Tifft CJ, Aksentijevich I, Kastner DL, Rocha PP, Werner A. Beck DB, et al. Among authors: rocha pp. Sci Adv. 2021 Jan 20;7(4):eabe2116. doi: 10.1126/sciadv.abe2116. Print 2021 Jan. Sci Adv. 2021. PMID: 33523931 Free PMC article.
Structural perturbation of chromatin domains with multiple developmental regulators can severely impact gene regulation and development.
Chakraborty S, Wenzlitschke N, Anderson MJ, Eraso A, Baudic M, Thompson JJ, Evans AA, Shatford-Adams LM, Chari R, Awasthi P, Dale RK, Lewandoski M, Petros TJ, Rocha PP. Chakraborty S, et al. Among authors: rocha pp. bioRxiv [Preprint]. 2024 Aug 3:2024.08.03.606480. doi: 10.1101/2024.08.03.606480. bioRxiv. 2024. PMID: 39372737 Free PMC article. Preprint.
A Tumor Suppressor Enhancer of PTEN in T-cell development and leukemia.
Tottone L, Lancho O, Loh JW, Singh A, Kimura S, Roels J, Kuchmiy A, Strubbe S, Lawlor MA, da Silva-Diz V, Luo S, Gachet S, García-Prieto CA, Hagelaar R, Esteller M, Meijerink JPP, Soulier J, Taghon T, Van Vlierberghe P, Mullighan CG, Khiabanian H, Rocha PP, Herranz D. Tottone L, et al. Among authors: rocha pp. Blood Cancer Discov. 2021 Jan;2(1):92-109. doi: 10.1158/2643-3230.BCD-20-0201. Epub 2020 Nov 24. Blood Cancer Discov. 2021. PMID: 33458694 Free PMC article.
Chromatin structure undergoes global and local reorganization during murine dendritic cell development and activation.
Kurotaki D, Kikuchi K, Cui K, Kawase W, Saeki K, Fukumoto J, Nishiyama A, Nagamune K, Zhao K, Ozato K, Rocha PP, Tamura T. Kurotaki D, et al. Among authors: rocha pp. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2207009119. doi: 10.1073/pnas.2207009119. Epub 2022 Aug 15. Proc Natl Acad Sci U S A. 2022. PMID: 35969760 Free PMC article.
44 results