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Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria.
Shuoker B, Pichler MJ, Jin C, Sakanaka H, Wu H, Gascueña AM, Liu J, Nielsen TS, Holgersson J, Nordberg Karlsson E, Juge N, Meier S, Morth JP, Karlsson NG, Abou Hachem M. Shuoker B, et al. Among authors: abou hachem m. Nat Commun. 2023 Apr 1;14(1):1833. doi: 10.1038/s41467-023-37533-6. Nat Commun. 2023. PMID: 37005422 Free PMC article.
Deletion of a cytotoxic, N-terminal putatitive signal peptide results in a significant increase in production yields in Escherichia coli and improved specific activity of Cel12A from Rhodothermus marinus.
Wicher KB, Abou-Hachem M, Halldórsdóttir S, Thorbjarnadóttir SH, Eggertsson G, Hreggvidsson GO, Nordberg Karlsson E, Holst O. Wicher KB, et al. Among authors: abou hachem m. Appl Microbiol Biotechnol. 2001 May;55(5):578-84. doi: 10.1007/s002530000559. Appl Microbiol Biotechnol. 2001. PMID: 11414324
Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways.
Pichler MJ, Yamada C, Shuoker B, Alvarez-Silva C, Gotoh A, Leth ML, Schoof E, Katoh T, Sakanaka M, Katayama T, Jin C, Karlsson NG, Arumugam M, Fushinobu S, Abou Hachem M. Pichler MJ, et al. Among authors: abou hachem m. Nat Commun. 2020 Jul 3;11(1):3285. doi: 10.1038/s41467-020-17075-x. Nat Commun. 2020. PMID: 32620774 Free PMC article.
Discovery of fungal oligosaccharide-oxidising flavo-enzymes with previously unknown substrates, redox-activity profiles and interplay with LPMOs.
Haddad Momeni M, Fredslund F, Bissaro B, Raji O, Vuong TV, Meier S, Nielsen TS, Lombard V, Guigliarelli B, Biaso F, Haon M, Grisel S, Henrissat B, Welner DH, Master ER, Berrin JG, Abou Hachem M. Haddad Momeni M, et al. Among authors: abou hachem m. Nat Commun. 2021 Apr 9;12(1):2132. doi: 10.1038/s41467-021-22372-0. Nat Commun. 2021. PMID: 33837197 Free PMC article.
64 results