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Novel CYP1B1-RMDN2 Alzheimer's disease locus identified by genome-wide association analysis of cerebral tau deposition on PET.
Nho K, Risacher SL, Apostolova L, Bice PJ, Brosch J, Deardorff R, Faber K, Farlow MR, Foroud T, Gao S, Rosewood T, Kim JP, Nudelman K, Yu M, Aisen P, Sperling R, Hooli B, Shcherbinin S, Svaldi D, Jack CR, Jagust WJ, Landau S, Vasanthakumar A, Waring JF, Doré V, Laws SM, Masters CL, Porter T, Rowe CC, Villemagne VL, Dumitrescu L, Hohman TJ, Libby JB, Mormino E, Buckley RF, Johnson K, Yang HS, Petersen RC, Ramanan VK, Vemuri P, Cohen AD, Fan KH, Kamboh MI, Lopez OL, Bennett DA, Ali M, Benzinger T, Cruchaga C, Hobbs D, De Jager PL, Fujita M, Jadhav V, Lamb BT, Tsai AP, Castanho I, Mill J, Weiner MW; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer’s Disease Neuroimaging Initiative – Department of Defense; Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study); Australian Imaging, Biomarker & Lifestyle Study (AIBL); Saykin AJ. Nho K, et al. Among authors: mill j. medRxiv [Preprint]. 2023 Mar 22:2023.02.27.23286048. doi: 10.1101/2023.02.27.23286048. medRxiv. 2023. PMID: 36993271 Free PMC article. Preprint.
CYP1B1-RMDN2 Alzheimer's disease endophenotype locus identified for cerebral tau PET.
Nho K, Risacher SL, Apostolova LG, Bice PJ, Brosch JR, Deardorff R, Faber K, Farlow MR, Foroud T, Gao S, Rosewood T, Kim JP, Nudelman K, Yu M, Aisen P, Sperling R, Hooli B, Shcherbinin S, Svaldi D, Jack CR Jr, Jagust WJ, Landau S, Vasanthakumar A, Waring JF, Doré V, Laws SM, Masters CL, Porter T, Rowe CC, Villemagne VL, Dumitrescu L, Hohman TJ, Libby JB, Mormino E, Buckley RF, Johnson K, Yang HS, Petersen RC, Ramanan VK, Ertekin-Taner N, Vemuri P, Cohen AD, Fan KH, Kamboh MI, Lopez OL, Bennett DA, Ali M, Benzinger T, Cruchaga C, Hobbs D, De Jager PL, Fujita M, Jadhav V, Lamb BT, Tsai AP, Castanho I, Mill J, Weiner MW; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Department of Defense Alzheimer’s Disease Neuroimaging Initiative (DoD-ADNI); Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN); Australian Imaging, Biomarker & Lifestyle Study (AIBL); Saykin AJ. Nho K, et al. Among authors: mill j. Nat Commun. 2024 Sep 20;15(1):8251. doi: 10.1038/s41467-024-52298-2. Nat Commun. 2024. PMID: 39304655 Free PMC article.
Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, Condliffe D, Harries LW, Katsel P, Haroutunian V, Kaminsky Z, Joachim C, Powell J, Lovestone S, Bennett DA, Schalkwyk LC, Mill J. Lunnon K, et al. Among authors: mill j. Nat Neurosci. 2014 Sep;17(9):1164-70. doi: 10.1038/nn.3782. Epub 2014 Aug 17. Nat Neurosci. 2014. PMID: 25129077 Free PMC article.
Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology.
Smith RG, Hannon E, De Jager PL, Chibnik L, Lott SJ, Condliffe D, Smith AR, Haroutunian V, Troakes C, Al-Sarraj S, Bennett DA, Powell J, Lovestone S, Schalkwyk L, Mill J, Lunnon K. Smith RG, et al. Among authors: mill j. Alzheimers Dement. 2018 Dec;14(12):1580-1588. doi: 10.1016/j.jalz.2018.01.017. Epub 2018 Mar 15. Alzheimers Dement. 2018. PMID: 29550519 Free PMC article.
A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex.
Smith RG, Pishva E, Shireby G, Smith AR, Roubroeks JAY, Hannon E, Wheildon G, Mastroeni D, Gasparoni G, Riemenschneider M, Giese A, Sharp AJ, Schalkwyk L, Haroutunian V, Viechtbauer W, van den Hove DLA, Weedon M, Brokaw D, Francis PT, Thomas AJ, Love S, Morgan K, Walter J, Coleman PD, Bennett DA, De Jager PL, Mill J, Lunnon K. Smith RG, et al. Among authors: mill j. Nat Commun. 2021 Jun 10;12(1):3517. doi: 10.1038/s41467-021-23243-4. Nat Commun. 2021. PMID: 34112773 Free PMC article.
Antidepressant Exposure and DNA Methylation: Insights from a Methylome-Wide Association Study.
Davyson E, Shen X, Huider F, Adams M, Borges K, McCartney D, Barker L, Van Dongen J, Boomsma D, Weihs A, Grabe H, Kühn L, Teumer A, Völzke H, Zhu T, Kaprio J, Ollikainen M, David FS, Meinert S, Stein F, Forstner AJ, Dannlowski U, Kircher T, Tapuc A, Czamara D, Binder EB, Brückl T, Kwong A, Yousefi P, Wong C, Arseneault L, Fisher HL, Mill J, Cox S, Redmond P, Russ TC, van den Oord E, Aberg KA, Penninx B, Marioni RE, Wray NR, McIntosh AM. Davyson E, et al. Among authors: mill j. medRxiv [Preprint]. 2024 May 3:2024.05.01.24306640. doi: 10.1101/2024.05.01.24306640. medRxiv. 2024. PMID: 38746357 Free PMC article. Preprint.
Transcriptional Signatures of Tau and Amyloid Neuropathology.
Castanho I, Murray TK, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, Moore K, O'Neill P, Lunnon K, Collier DA, Ahmed Z, O'Neill MJ, Mill J. Castanho I, et al. Among authors: mill j. Cell Rep. 2020 Feb 11;30(6):2040-2054.e5. doi: 10.1016/j.celrep.2020.01.063. Cell Rep. 2020. PMID: 32049030 Free PMC article.
Long-read transcript sequencing identifies differential isoform expression in the entorhinal cortex in a transgenic model of tau pathology.
Leung SK, Bamford RA, Jeffries AR, Castanho I, Chioza B, Flaxman CS, Moore K, Dempster EL, Harvey J, Brown JT, Ahmed Z, O'Neill P, Richardson SJ, Hannon E, Mill J. Leung SK, et al. Among authors: mill j. Nat Commun. 2024 Aug 2;15(1):6458. doi: 10.1038/s41467-024-50486-8. Nat Commun. 2024. PMID: 39095344 Free PMC article.
800 results