Jafar-Nejad P - Search Results

1

Differential effects of SARM1 inhibition in traumatic glaucoma and EAE optic neuropathies.

Liu P, Chen W, Jiang H, Huang H, Liu L, Fang F, Li L, Feng X, Liu D, Dalal R, Sun Y, Jafar-Nejad P, Ling K, Rigo F, Ye J, Hu Y. Liu P, et al. Mol Ther Nucleic Acids. 2023 Feb 27;32:13-27. doi: 10.1016/j.omtn.2023.02.029. eCollection 2023 Jun 13. Mol Ther Nucleic Acids. 2023. PMID: 36950280 Free PMC article.

2

Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD.

Luan W, Wright AL, Brown-Wright H, Le S, San Gil R, Madrid San Martin L, Ling K, Jafar-Nejad P, Rigo F, Walker AK. Luan W, et al. Mol Psychiatry. 2023 Jun;28(6):2445-2461. doi: 10.1038/s41380-023-02036-9. Epub 2023 Apr 3. Mol Psychiatry. 2023. PMID: 37012334 Free PMC article.

3

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport.

Yang S, Niou ZX, Enriquez A, LaMar J, Huang JY, Ling K, Jafar-Nejad P, Gilley J, Coleman MP, Tennessen JM, Rangaraju V, Lu HC. Yang S, et al. Res Sq [Preprint]. 2023 May 19:rs.3.rs-2859584. doi: 10.21203/rs.3.rs-2859584/v1. Res Sq. 2023. Update in: Mol Neurodegener. 2024 Jan 29;19(1):13. doi: 10.1186/s13024-023-00690-9 PMID: 37292715 Free PMC article. Updated. Preprint.

4

Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes.

Torazza C, Provenzano F, Gallia E, Cerminara M, Balbi M, Bonifacino T, Tessitore S, Ravera S, Usai C, Musante I, Puliti A, Van Den Bosch L, Jafar-Nejad P, Rigo F, Milanese M, Bonanno G. Torazza C, et al. Cells. 2023 Jul 27;12(15):1952. doi: 10.3390/cells12151952. Cells. 2023. PMID: 37566031 Free PMC article.

5

Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation.

Aggarwal G, Banerjee S, Jones SA, Benchaar Y, Bélanger J, Sévigny M, Smith DM, Niehoff ML, Pavlack M, de Vera IMS, Petkau TL, Leavitt BR, Ling K, Jafar-Nejad P, Rigo F, Morley JE, Farr SA, Dutchak PA, Sephton CF, Nguyen AD. Aggarwal G, et al. J Biol Chem. 2023 Dec;299(12):105475. doi: 10.1016/j.jbc.2023.105475. Epub 2023 Nov 18. J Biol Chem. 2023. PMID: 37981208 Free PMC article.

6

Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation.

López-Erauskin J, Bravo-Hernandez M, Presa M, Baughn MW, Melamed Z, Beccari MS, Agra de Almeida Quadros AR, Arnold-Garcia O, Zuberi A, Ling K, Platoshyn O, Niño-Jara E, Ndayambaje IS, McAlonis-Downes M, Cabrera L, Artates JW, Ryan J, Hermann A, Ravits J, Bennett CF, Jafar-Nejad P, Rigo F, Marsala M, Lutz CM, Cleveland DW, Lagier-Tourenne C. López-Erauskin J, et al. Nat Neurosci. 2024 Jan;27(1):34-47. doi: 10.1038/s41593-023-01496-0. Epub 2023 Nov 23. Nat Neurosci. 2024. PMID: 37996528 Free PMC article.

7

G₂C₄ targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons.

Rothstein JD, Baskerville V, Rapuri S, Mehlhop E, Jafar-Nejad P, Rigo F, Bennett F, Mizielinska S, Isaacs A, Coyne AN. Rothstein JD, et al. Among authors: jafar nejad p. Acta Neuropathol. 2023 Nov 29;147(1):1. doi: 10.1007/s00401-023-02652-3. Acta Neuropathol. 2023. PMID: 38019311 Free PMC article.

8

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport.

Yang S, Niou ZX, Enriquez A, LaMar J, Huang JY, Ling K, Jafar-Nejad P, Gilley J, Coleman MP, Tennessen JM, Rangaraju V, Lu HC. Yang S, et al. Among authors: jafar nejad p. Mol Neurodegener. 2024 Jan 29;19(1):13. doi: 10.1186/s13024-023-00690-9. Mol Neurodegener. 2024. PMID: 38282024 Free PMC article.

9

Reduction of RAD23A extends lifespan and mitigates pathology in TDP-43 mice.

Guo X, Prajapati R, Chun J, Byun I, Gebis KK, Wang YZ, Ling K, Dalton C, Blair JA, Hamidianjahromi A, Bachmann G, Rigo F, Jafar-Nejad P, Savas JN, Lee MJ, Sreedharan J, Kalb RG. Guo X, et al. Among authors: jafar nejad p. bioRxiv [Preprint]. 2024 Sep 14:2024.09.10.612226. doi: 10.1101/2024.09.10.612226. bioRxiv. 2024. PMID: 39314471 Free PMC article. Preprint.

10

Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study.

van den Berg LH, Rothstein JD, Shaw PJ, Babu S, Benatar M, Bucelli RC, Genge A, Glass JD, Hardiman O, Libri V, Mobach T, Oskarsson B, Pattee GL, Ravits J, Shaw CE, Weber M, Zinman L, Jafar-Nejad P, Rigo F, Lin L, Ferguson TA, Gotter AL, Graham D, Monine M, Inra J, Sinks S, Eraly S, Garafalo S, Fradette S. van den Berg LH, et al. Among authors: jafar nejad p. Lancet Neurol. 2024 Sep;23(9):901-912. doi: 10.1016/S1474-4422(24)00216-3. Epub 2024 Jul 23. Lancet Neurol. 2024. PMID: 39059407 Clinical Trial.

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