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Dynamic network-guided CRISPRi screen reveals CTCF loop-constrained nonlinear enhancer-gene regulatory activity in cell state transitions.
Luo R, Yan J, Oh JW, Xi W, Shigaki D, Wong W, Cho H, Murphy D, Cutler R, Rosen BP, Pulecio J, Yang D, Glenn R, Chen T, Li QV, Vierbuchen T, Sidoli S, Apostolou E, Huangfu D, Beer MA. Luo R, et al. Among authors: pulecio j. bioRxiv [Preprint]. 2023 Mar 9:2023.03.07.531569. doi: 10.1101/2023.03.07.531569. bioRxiv. 2023. Update in: Nat Genet. 2023 Aug;55(8):1336-1346. doi: 10.1038/s41588-023-01450-7. PMID: 36945628 Free PMC article. Updated. Preprint.
Discovery of Competent Chromatin Regions in Human Embryonic Stem Cells.
Pulecio J, Tayyebi Z, Liu D, Wong W, Luo R, Damodaran JR, Kaplan S, Cho H, Yan J, Murphy D, Rickert RW, Shukla A, Zhong A, González F, Yang D, Li W, Zhou T, Apostolou E, Leslie CS, Huangfu D. Pulecio J, et al. bioRxiv [Preprint]. 2023 Jun 14:2023.06.14.544990. doi: 10.1101/2023.06.14.544990. bioRxiv. 2023. PMID: 37398096 Free PMC article. Preprint.
CRISPR Screening Uncovers a Long-Range Enhancer for ONECUT1 in Pancreatic Differentiation and Links a Diabetes Risk Variant.
Kaplan SJ, Wong W, Yan J, Pulecio J, Cho HS, Li Q, Zhao J, Leslie-Iyer J, Kazakov J, Murphy D, Luo R, Dey KK, Apostolou E, Leslie CS, Huangfu D. Kaplan SJ, et al. Among authors: pulecio j. bioRxiv [Preprint]. 2024 Jun 28:2024.04.26.591412. doi: 10.1101/2024.04.26.591412. bioRxiv. 2024. Update in: Cell Rep. 2024 Aug 27;43(8):114640. doi: 10.1016/j.celrep.2024.114640. PMID: 38746154 Free PMC article. Updated. Preprint.
Glucose Transporters Are Key Components of the Human Glucostat.
Caspi I, Tremmel DM, Pulecio J, Yang D, Liu D, Yan J, Odorico JS, Huangfu D. Caspi I, et al. Among authors: pulecio j. Diabetes. 2024 Aug 1;73(8):1336-1351. doi: 10.2337/db23-0508. Diabetes. 2024. PMID: 38775784 Free PMC article.
Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions.
Luo R, Yan J, Oh JW, Xi W, Shigaki D, Wong W, Cho HS, Murphy D, Cutler R, Rosen BP, Pulecio J, Yang D, Glenn RA, Chen T, Li QV, Vierbuchen T, Sidoli S, Apostolou E, Huangfu D, Beer MA. Luo R, et al. Among authors: pulecio j. Nat Genet. 2023 Aug;55(8):1336-1346. doi: 10.1038/s41588-023-01450-7. Epub 2023 Jul 24. Nat Genet. 2023. PMID: 37488417 Free PMC article.
CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction.
Yang D, Cho H, Tayyebi Z, Shukla A, Luo R, Dixon G, Ursu V, Stransky S, Tremmel DM, Sackett SD, Koche R, Kaplan SJ, Li QV, Park J, Zhu Z, Rosen BP, Pulecio J, Shi ZD, Bram Y, Schwartz RE, Odorico JS, Sidoli S, Wright CV, Leslie CS, Huangfu D. Yang D, et al. Among authors: pulecio j. Nat Cell Biol. 2022 Jul;24(7):1064-1076. doi: 10.1038/s41556-022-00946-4. Epub 2022 Jul 4. Nat Cell Biol. 2022. PMID: 35787684 Free PMC article.
QSER1 protects DNA methylation valleys from de novo methylation.
Dixon G, Pan H, Yang D, Rosen BP, Jashari T, Verma N, Pulecio J, Caspi I, Lee K, Stransky S, Glezer A, Liu C, Rivas M, Kumar R, Lan Y, Torregroza I, He C, Sidoli S, Evans T, Elemento O, Huangfu D. Dixon G, et al. Among authors: pulecio j. Science. 2021 Apr 9;372(6538):eabd0875. doi: 10.1126/science.abd0875. Science. 2021. PMID: 33833093 Free PMC article.
Author Correction: Conversion of human fibroblasts to angioblast-like progenitor cells.
Kurian L, Sancho-Martinez I, Nivet E, Aguirre A, Moon K, Pendaries C, Volle-Challier C, Bono F, Herbert JM, Pulecio J, Xia Y, Li M, Montserrat N, Ruiz S, Dubova I, Rodriguez C, Denli AM, Boscolo FS, Thiagarajan RD, Gage FH, Loring JF, Laurent LC, Belmonte JCI. Kurian L, et al. Among authors: pulecio j. Nat Methods. 2020 Mar;17(3):353. doi: 10.1038/s41592-020-0745-8. Nat Methods. 2020. PMID: 32034376
21 results