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O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology.
Balana AT, Mahul-Mellier AL, Nguyen BA, Horvath M, Javed A, Hard ER, Jasiqi Y, Singh P, Afrin S, Pedretti R, Singh V, Lee VM, Luk KC, Saelices L, Lashuel HA, Pratt MR. Balana AT, et al. bioRxiv [Preprint]. 2023 Mar 7:2023.03.07.531573. doi: 10.1101/2023.03.07.531573. bioRxiv. 2023. Update in: Nat Chem Biol. 2024 May;20(5):646-655. doi: 10.1038/s41589-024-01551-2 PMID: 36945566 Free PMC article. Updated. Preprint.
O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity.
Levine PM, Balana AT, Sturchler E, Koole C, Noda H, Zarzycka B, Daley EJ, Truong TT, Katritch V, Gardella TJ, Wootten D, Sexton PM, McDonald P, Pratt MR. Levine PM, et al. Among authors: balana at. J Am Chem Soc. 2019 Sep 11;141(36):14210-14219. doi: 10.1021/jacs.9b05365. Epub 2019 Aug 28. J Am Chem Soc. 2019. PMID: 31418572 Free PMC article.
19 results