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A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function.
Lyon M, Li P, Ferreira JJ, Lazarenko RM, Kharade SV, Kramer M, McClenahan SJ, Days E, Bauer JA, Spitznagel BD, Weaver CD, Borrego Alvarez A, Puga Molina LC, Lybaert P, Khambekar S, Liu A, Lindsley CW, Denton J, Santi CM. Lyon M, et al. Among authors: lindsley cw. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2212338120. doi: 10.1073/pnas.2212338120. Epub 2023 Jan 17. Proc Natl Acad Sci U S A. 2023. PMID: 36649421 Free PMC article.
Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS.
Dodd CJ, Chronister KS, Rathnayake U, Parr LC, Li K, Chang S, Mi D, Days EL, Bauer JA, Cho HP, Boutaud O, Denton JS, Lindsley CW, Han C. Dodd CJ, et al. Among authors: lindsley cw. Bioorg Med Chem Lett. 2023 May 1;87:129256. doi: 10.1016/j.bmcl.2023.129256. Epub 2023 Mar 24. Bioorg Med Chem Lett. 2023. PMID: 36966977 Free PMC article.
Development of a Peripherally Restricted 5-HT2B Partial Agonist for Treatment of Pulmonary Arterial Hypertension.
Valentine MS, Bender AM, Shay S, Paffenroth KC, Gladson S, Dickerson JW, Watson KJ, Kapolka NJ, Boutaud O, Rook JM, Blackwell TS, Roth BL, Harrison FE, Austin ED, West JD, Lindsley CW, Merryman WD. Valentine MS, et al. Among authors: lindsley cw. JACC Basic Transl Sci. 2023 Sep 13;8(10):1379-1388. doi: 10.1016/j.jacbts.2023.06.014. eCollection 2023 Oct. JACC Basic Transl Sci. 2023. PMID: 38094686 Free PMC article.
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.
Vuckovic Z, Wang J, Pham V, Mobbs JI, Belousoff MJ, Bhattarai A, Burger WAC, Thompson G, Yeasmin M, Nawaratne V, Leach K, van der Westhuizen ET, Khajehali E, Liang YL, Glukhova A, Wootten D, Lindsley CW, Tobin A, Sexton P, Danev R, Valant C, Miao Y, Christopoulos A, Thal DM. Vuckovic Z, et al. Among authors: lindsley cw. Elife. 2023 May 30;12:e83477. doi: 10.7554/eLife.83477. Elife. 2023. PMID: 37248726 Free PMC article.
Co-stimulation of muscarinic M1 and M4 acetylcholine receptors prevents later cocaine reinforcement in male and female mice, but not place-conditioning.
Balakrishnan AS, Johansen LBE, Lindsley CW, Conn PJ, Thomsen M. Balakrishnan AS, et al. Among authors: lindsley cw. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Aug 30;134:111079. doi: 10.1016/j.pnpbp.2024.111079. Epub 2024 Jun 29. Prog Neuropsychopharmacol Biol Psychiatry. 2024. PMID: 38950842 Free article.
757 results