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SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.
Asano F, Kim SJ, Fujiyama T, Miyoshi C, Hotta-Hirashima N, Asama N, Iwasaki K, Kakizaki M, Mizuno S, Mieda M, Sugiyama F, Takahashi S, Shi S, Hirano A, Funato H, Yanagisawa M. Asano F, et al. Among authors: fujiyama t. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2218209120. doi: 10.1073/pnas.2218209120. Epub 2023 Mar 6. Proc Natl Acad Sci U S A. 2023. PMID: 36877841 Free PMC article.
Identification of mutations through dominant screening for obesity using C57BL/6 substrains.
Hossain MS, Asano F, Fujiyama T, Miyoshi C, Sato M, Ikkyu A, Kanno S, Hotta N, Kakizaki M, Honda T, Kim SJ, Komiya H, Miura I, Suzuki T, Kobayashi K, Kaneda H, Kumar V, Takahashi JS, Wakana S, Funato H, Yanagisawa M. Hossain MS, et al. Among authors: fujiyama t. Sci Rep. 2016 Sep 2;6:32453. doi: 10.1038/srep32453. Sci Rep. 2016. PMID: 27585985 Free PMC article.
Forward-genetics analysis of sleep in randomly mutagenized mice.
Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi JS, Yanagisawa M. Funato H, et al. Among authors: fujiyama t. Nature. 2016 Nov 17;539(7629):378-383. doi: 10.1038/nature20142. Epub 2016 Nov 2. Nature. 2016. PMID: 27806374 Free PMC article.
Quantitative phosphoproteomic analysis of the molecular substrates of sleep need.
Wang Z, Ma J, Miyoshi C, Li Y, Sato M, Ogawa Y, Lou T, Ma C, Gao X, Lee C, Fujiyama T, Yang X, Zhou S, Hotta-Hirashima N, Klewe-Nebenius D, Ikkyu A, Kakizaki M, Kanno S, Cao L, Takahashi S, Peng J, Yu Y, Funato H, Yanagisawa M, Liu Q. Wang Z, et al. Among authors: fujiyama t. Nature. 2018 Jun;558(7710):435-439. doi: 10.1038/s41586-018-0218-8. Epub 2018 Jun 13. Nature. 2018. PMID: 29899451 Free PMC article.
Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain.
Fujiyama T, Miyashita S, Tsuneoka Y, Kanemaru K, Kakizaki M, Kanno S, Ishikawa Y, Yamashita M, Owa T, Nagaoka M, Kawaguchi Y, Yanagawa Y, Magnuson MA, Muratani M, Shibuya A, Nabeshima YI, Yanagisawa M, Funato H, Hoshino M. Fujiyama T, et al. Cell Rep. 2018 Jul 3;24(1):79-94. doi: 10.1016/j.celrep.2018.06.010. Cell Rep. 2018. PMID: 29972793 Free article.
A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice.
Honda T, Fujiyama T, Miyoshi C, Ikkyu A, Hotta-Hirashima N, Kanno S, Mizuno S, Sugiyama F, Takahashi S, Funato H, Yanagisawa M. Honda T, et al. Among authors: fujiyama t. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10458-10463. doi: 10.1073/pnas.1810823115. Epub 2018 Sep 25. Proc Natl Acad Sci U S A. 2018. PMID: 30254177 Free PMC article.
Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.
Park M, Miyoshi C, Fujiyama T, Kakizaki M, Ikkyu A, Honda T, Choi J, Asano F, Mizuno S, Takahashi S, Yanagisawa M, Funato H. Park M, et al. Among authors: fujiyama t. Sci Rep. 2020 May 26;10(1):8676. doi: 10.1038/s41598-020-65647-0. Sci Rep. 2020. PMID: 32457359 Free PMC article.
Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β.
Nakai A, Fujiyama T, Nagata N, Kashiwagi M, Ikkyu A, Takagi M, Tatsuzawa C, Tanaka K, Kakizaki M, Kanuka M, Kawano T, Mizuno S, Sugiyama F, Takahashi S, Funato H, Sakurai T, Yanagisawa M, Hayashi Y. Nakai A, et al. Among authors: fujiyama t. Genetics. 2020 Nov;216(3):753-764. doi: 10.1534/genetics.120.303435. Epub 2020 Sep 2. Genetics. 2020. PMID: 32878901 Free PMC article.
Induction of Mutant Sik3Sleepy Allele in Neurons in Late Infancy Increases Sleep Need.
Iwasaki K, Fujiyama T, Nakata S, Park M, Miyoshi C, Hotta-Hirashima N, Ikkyu A, Kakizaki M, Sugiyama F, Mizuno S, Abe M, Sakimura K, Takahashi S, Funato H, Yanagisawa M. Iwasaki K, et al. Among authors: fujiyama t. J Neurosci. 2021 Mar 24;41(12):2733-2746. doi: 10.1523/JNEUROSCI.1004-20.2020. Epub 2021 Feb 8. J Neurosci. 2021. PMID: 33558433 Free PMC article.
128 results