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214 results

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Local senolysis in aged mice only partially replicates the benefits of systemic senolysis.
Farr JN, Saul D, Doolittle ML, Kaur J, Rowsey JL, Vos SJ, Froemming MN, Lagnado AB, Zhu Y, Weivoda M, Ikeno Y, Pignolo RJ, Niedernhofer LJ, Robbins PD, Jurk D, Passos JF, LeBrasseur NK, Tchkonia T, Kirkland JL, Monroe DG, Khosla S. Farr JN, et al. Among authors: ikeno y. J Clin Invest. 2023 Apr 17;133(8):e162519. doi: 10.1172/JCI162519. J Clin Invest. 2023. PMID: 36809340 Free PMC article.
HADHA Regulates Respiratory Complex Assembly and Couples FAO and OXPHOS.
Qin C, Gong S, Liang T, Zhang Z, Thomas J, Deng J, Liu Y, Hu P, Zhu B, Song S, Ortiz MF, Ikeno Y, Wang E, Lechleiter J, Weintraub ST, Bai Y. Qin C, et al. Among authors: ikeno y. Adv Sci (Weinh). 2024 Nov 3:e2405147. doi: 10.1002/advs.202405147. Online ahead of print. Adv Sci (Weinh). 2024. PMID: 39488787
Targeting S6K/NFκB/SQSTM1/Polθ signaling to suppress radiation resistance in prostate cancer.
Clark A, Villarreal MR, Huang SB, Jayamohan S, Rivas P, Hussain SS, Ybarra M, Osmulski P, Gaczynska ME, Shim EY, Smith T, Gupta YK, Yang X, Delma CR, Natarajan M, Lai Z, Wang LJ, Michalek JE, Higginson DS, Ikeno Y, Ha CS, Chen Y, Ghosh R, Kumar AP. Clark A, et al. Among authors: ikeno y. Cancer Lett. 2024 Aug 10;597:217063. doi: 10.1016/j.canlet.2024.217063. Epub 2024 Jun 24. Cancer Lett. 2024. PMID: 38925361 Free article.
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function.
Wang B, Wang L, Gasek NS, Kuo CL, Nie J, Kim T, Yan P, Zhu J, Torrance BL, Zhou Y, Flores LC, Allen C, Andrade AM, Guo C, Cohn RL, Jellison ER, Bartley JM, Kuchel GA, Li S, Pirtskhalava T, Tchkonia T, Yadav S, Haynes L, Kirkland JL, Ikeno Y, Xu M. Wang B, et al. Among authors: ikeno y. Cell Metab. 2024 Aug 6;36(8):1795-1805.e6. doi: 10.1016/j.cmet.2024.07.006. Cell Metab. 2024. PMID: 39111286
Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner.
Kane AE, Chellappa K, Schultz MB, Arnold M, Li J, Amorim J, Diener C, Zhu D, Mitchell SJ, Griffin P, Tian X, Petty C, Conway R, Walsh K, Shelerud L, Duesing C, Mueller A, Li K, McNamara M, Shima RT, Mitchell J, Bonkowski MS, de Cabo R, Gibbons SM, Wu LE, Ikeno Y, Baur JA, Rajman L, Sinclair DA. Kane AE, et al. Among authors: ikeno y. bioRxiv [Preprint]. 2024 Jun 27:2024.06.21.599604. doi: 10.1101/2024.06.21.599604. bioRxiv. 2024. PMID: 38979132 Free PMC article. Preprint.
214 results