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The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability.
Ravn-Boess N, Roy N, Hattori T, Bready D, Donaldson H, Lawson C, Lapierre C, Korman A, Rodrick T, Liu E, Frenster JD, Stephan G, Wilcox J, Corrado AD, Cai J, Ronnen R, Wang S, Haddock S, Sabio Ortiz J, Mishkit O, Khodadadi-Jamayran A, Tsirigos A, Fenyö D, Zagzag D, Drube J, Hoffmann C, Perna F, Jones DR, Possemato R, Koide A, Koide S, Park CY, Placantonakis DG. Ravn-Boess N, et al. Among authors: bready d. Cell Rep. 2023 Nov 28;42(11):113374. doi: 10.1016/j.celrep.2023.113374. Epub 2023 Nov 8. Cell Rep. 2023. PMID: 37938973 Free PMC article.
PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma.
Frenster JD, Erdjument-Bromage H, Stephan G, Ravn-Boess N, Wang S, Liu W, Bready D, Wilcox J, Kieslich B, Jankovic M, Wilde C, Horn S, Sträter N, Liebscher I, Schöneberg T, Fenyo D, Neubert TA, Placantonakis DG. Frenster JD, et al. Among authors: bready d. Cell Rep. 2023 Jul 25;42(7):112679. doi: 10.1016/j.celrep.2023.112679. Epub 2023 Jun 23. Cell Rep. 2023. PMID: 37354459 Free PMC article.
Modulation of GPR133 (ADGRD1) Signaling by its Intracellular Interaction Partner Extended Synaptotagmin 1 (ESYT1).
Stephan G, Erdjument-Bromage H, Liu W, Frenster JD, Ravn-Boess N, Bready D, Cai J, Fenyo D, Neubert T, Placantonakis DG. Stephan G, et al. Among authors: bready d. bioRxiv [Preprint]. 2023 Feb 9:2023.02.09.527921. doi: 10.1101/2023.02.09.527921. bioRxiv. 2023. Update in: Cell Rep. 2024 May 28;43(5):114229. doi: 10.1016/j.celrep.2024.114229 PMID: 36798364 Free PMC article. Updated. Preprint.
The H3K36me2 writer-reader dependency in H3K27M-DIPG.
Yu JR, LeRoy G, Bready D, Frenster JD, Saldaña-Meyer R, Jin Y, Descostes N, Stafford JM, Placantonakis DG, Reinberg D. Yu JR, et al. Among authors: bready d. Sci Adv. 2021 Jul 14;7(29):eabg7444. doi: 10.1126/sciadv.abg7444. Print 2021 Jul. Sci Adv. 2021. PMID: 34261657 Free PMC article.
Functional impact of intramolecular cleavage and dissociation of adhesion G protein-coupled receptor GPR133 (ADGRD1) on canonical signaling.
Frenster JD, Stephan G, Ravn-Boess N, Bready D, Wilcox J, Kieslich B, Wilde C, Sträter N, Wiggin GR, Liebscher I, Schöneberg T, Placantonakis DG. Frenster JD, et al. Among authors: bready d. J Biol Chem. 2021 Jan-Jun;296:100798. doi: 10.1016/j.jbc.2021.100798. Epub 2021 May 20. J Biol Chem. 2021. PMID: 34022221 Free PMC article.
Expression profiling of the adhesion G protein-coupled receptor GPR133 (ADGRD1) in glioma subtypes.
Frenster JD, Kader M, Kamen S, Sun J, Chiriboga L, Serrano J, Bready D, Golub D, Ravn-Boess N, Stephan G, Chi AS, Kurz SC, Jain R, Park CY, Fenyo D, Liebscher I, Schöneberg T, Wiggin G, Newman R, Barnes M, Dickson JK, MacNeil DJ, Huang X, Shohdy N, Snuderl M, Zagzag D, Placantonakis DG. Frenster JD, et al. Among authors: bready d. Neurooncol Adv. 2020 Apr 28;2(1):vdaa053. doi: 10.1093/noajnl/vdaa053. eCollection 2020 Jan-Dec. Neurooncol Adv. 2020. PMID: 32642706 Free PMC article.
Molecular Pathogenesis of Low-Grade Glioma.
Bready D, Placantonakis DG. Bready D, et al. Neurosurg Clin N Am. 2019 Jan;30(1):17-25. doi: 10.1016/j.nec.2018.08.011. Neurosurg Clin N Am. 2019. PMID: 30470401 Free PMC article. Review.
13 results