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Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN-derived networks and highlights causal links in Alzheimer's disease.
Shi L, Xu J, Green R, Wretlind A, Homann J, Buckley NJ, Tijms BM, Vos SJB, Lill CM, Kate MT, Engelborghs S, Sleegers K, Frisoni GB, Wallin A, Lleó A, Popp J, Martinez-Lage P, Streffer J, Barkhof F, Zetterberg H, Visser PJ, Lovestone S, Bertram L, Nevado-Holgado AJ, Proitsi P, Legido-Quigley C. Shi L, et al. Among authors: buckley nj. Alzheimers Dement. 2023 Aug;19(8):3350-3364. doi: 10.1002/alz.12961. Epub 2023 Feb 15. Alzheimers Dement. 2023. PMID: 36790009
Predicting AT(N) pathologies in Alzheimer's disease from blood-based proteomic data using neural networks.
Zhang Y, Ghose U, Buckley NJ, Engelborghs S, Sleegers K, Frisoni GB, Wallin A, Lleó A, Popp J, Martinez-Lage P, Legido-Quigley C, Barkhof F, Zetterberg H, Visser PJ, Bertram L, Lovestone S, Nevado-Holgado AJ, Shi L. Zhang Y, et al. Among authors: buckley nj. Front Aging Neurosci. 2022 Nov 29;14:1040001. doi: 10.3389/fnagi.2022.1040001. eCollection 2022. Front Aging Neurosci. 2022. PMID: 36523958 Free PMC article.
Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life.
Walker KA, Chen J, Shi L, Yang Y, Fornage M, Zhou L, Schlosser P, Surapaneni A, Grams ME, Duggan MR, Peng Z, Gomez GT, Tin A, Hoogeveen RC, Sullivan KJ, Ganz P, Lindbohm JV, Kivimaki M, Nevado-Holgado AJ, Buckley N, Gottesman RF, Mosley TH, Boerwinkle E, Ballantyne CM, Coresh J. Walker KA, et al. Sci Transl Med. 2023 Jul 19;15(705):eadf5681. doi: 10.1126/scitranslmed.adf5681. Epub 2023 Jul 19. Sci Transl Med. 2023. PMID: 37467317 Free PMC article.
Paired plasma lipidomics and proteomics analysis in the conversion from mild cognitive impairment to Alzheimer's disease.
Gómez-Pascual A, Naccache T, Xu J, Hooshmand K, Wretlind A, Gabrielli M, Lombardo MT, Shi L, Buckley NJ, Tijms BM, Vos SJB, Ten Kate M, Engelborghs S, Sleegers K, Frisoni GB, Wallin A, Lleó A, Popp J, Martinez-Lage P, Streffer J, Barkhof F, Zetterberg H, Visser PJ, Lovestone S, Bertram L, Nevado-Holgado AJ, Gualerzi A, Picciolini S, Proitsi P, Verderio C, Botía JA, Legido-Quigley C. Gómez-Pascual A, et al. Among authors: buckley nj. Comput Biol Med. 2024 Jun;176:108588. doi: 10.1016/j.compbiomed.2024.108588. Epub 2024 May 13. Comput Biol Med. 2024. PMID: 38761503 Free article.
Plasma proteome-wide analysis of cerebral small vessel disease identifies novel biomarkers and disease pathways.
Gomez GT, Shi L, Fohner AE, Chen J, Yang Y, Fornage M, Duggan MR, Peng Z, Daya GN, Tin A, Schlosser P, Longstreth WT, Kalani R, Sharma M, Psaty BM, Nevado-Holgado AJ, Buckley NJ, Gottesman RF, Lutsey PL, Jack CR, Sullivan KJ, Mosley T, Hughes TM, Coresh J, Walker KA. Gomez GT, et al. Among authors: buckley nj. medRxiv [Preprint]. 2024 Oct 8:2024.10.07.24314972. doi: 10.1101/2024.10.07.24314972. medRxiv. 2024. PMID: 39417098 Free PMC article. Preprint.
Glycosylated clusterin species facilitate Aβ toxicity in human neurons.
Foster EM, Fernandes M, Dangla-Valls A, Hublitz P, Pangalos M, Lovestone S, Ribe EM, Buckley NJ. Foster EM, et al. Among authors: buckley nj. Sci Rep. 2022 Nov 3;12(1):18639. doi: 10.1038/s41598-022-23167-z. Sci Rep. 2022. PMID: 36329114 Free PMC article.
Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability.
Ng B, Rowland HA, Wei T, Arunasalam K, Hayes EM, Koychev I, Hedegaard A, Ribe EM, Chan D, Chessell T, Ffytche D, Gunn RN, Kocagoncu E, Lawson J, Malhotra PA, Ridha BH, Rowe JB, Thomas AJ, Zamboni G, Buckley NJ, Cader ZM, Lovestone S, Wade-Martins R. Ng B, et al. Among authors: buckley nj. Brain Commun. 2022 Oct 21;4(6):fcac267. doi: 10.1093/braincomms/fcac267. eCollection 2022. Brain Commun. 2022. PMID: 36349119 Free PMC article.
125 results