Ortlund EA - Search Results

1

The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits.

Mays SG, Hercules D, Ortlund EA, Okafor CD. Mays SG, et al. Among authors: ortlund ea. bioRxiv [Preprint]. 2023 Jan 28:2023.01.27.525934. doi: 10.1101/2023.01.27.525934. bioRxiv. 2023. Update in: Protein Sci. 2023 Oct;32(10):e4754. doi: 10.1002/pro.4754 PMID: 36747705 Free PMC article. Updated. Preprint.

2

Up-regulation of thioesterase superfamily member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance in mice.

Imai N, Nicholls HT, Alves-Bezerra M, Li Y, Ivanova AA, Ortlund EA, Cohen DE. Imai N, et al. Among authors: ortlund ea. Hepatology. 2022 Jan;75(1):154-169. doi: 10.1002/hep.32122. Epub 2021 Dec 8. Hepatology. 2022. PMID: 34433228 Free PMC article.

3

Lactococcus lactis Subspecies cremoris Elicits Protection Against Metabolic Changes Induced by a Western-Style Diet.

Naudin CR, Maner-Smith K, Owens JA, Wynn GM, Robinson BS, Matthews JD, Reedy AR, Luo L, Wolfarth AA, Darby TM, Ortlund EA, Jones RM. Naudin CR, et al. Among authors: ortlund ea. Gastroenterology. 2020 Aug;159(2):639-651.e5. doi: 10.1053/j.gastro.2020.03.010. Epub 2020 Mar 10. Gastroenterology. 2020. PMID: 32169430

4

DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining.

Head PE, Kapoor-Vazirani P, Nagaraju GP, Zhang H, Rath SK, Luong NC, Haji-Seyed-Javadi R, Sesay F, Wang SY, Duong DM, Daddacha W, Minten EV, Song B, Danelia D, Liu X, Li S, Ortlund EA, Seyfried NT, Smalley DM, Wang Y, Deng X, Dynan WS, El-Rayes B, Davis AJ, Yu DS. Head PE, et al. Among authors: ortlund ea. Nucleic Acids Res. 2023 Aug 25;51(15):7972-7987. doi: 10.1093/nar/gkad549. Nucleic Acids Res. 2023. PMID: 37395399 Free PMC article.

5

X-ray crystal structure of the ancestral 3-ketosteroid receptor-progesterone-mifepristone complex shows mifepristone bound at the coactivator binding interface.

Colucci JK, Ortlund EA. Colucci JK, et al. Among authors: ortlund ea. PLoS One. 2013 Nov 19;8(11):e80761. doi: 10.1371/journal.pone.0080761. eCollection 2013. PLoS One. 2013. PMID: 24260475 Free PMC article.

6

Nucleotide Binding to ARL2 in the TBCD∙ARL2∙β-Tubulin Complex Drives Conformational Changes in β-Tubulin.

Francis JW, Goswami D, Novick SJ, Pascal BD, Weikum ER, Ortlund EA, Griffin PR, Kahn RA. Francis JW, et al. Among authors: ortlund ea. J Mol Biol. 2017 Nov 24;429(23):3696-3716. doi: 10.1016/j.jmb.2017.09.016. Epub 2017 Sep 29. J Mol Biol. 2017. PMID: 28970104 Free PMC article.

7

Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site.

Ortlund E, Parker CL, Schreck SF, Ginell S, Minor W, Sodetz JM, Lebioda L. Ortlund E, et al. Biochemistry. 2002 Jun 4;41(22):7030-7. doi: 10.1021/bi025696i. Biochemistry. 2002. PMID: 12033936

8

Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor.

Bridgham JT, Keay J, Ortlund EA, Thornton JW. Bridgham JT, et al. Among authors: ortlund ea. PLoS Genet. 2014 Jan;10(1):e1004058. doi: 10.1371/journal.pgen.1004058. Epub 2014 Jan 9. PLoS Genet. 2014. PMID: 24415950 Free PMC article.

9

Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice.

Li Y, Imai N, Nicholls HT, Roberts BR, Goyal S, Krisko TI, Ang LH, Tillman MC, Roberts AM, Baqai M, Ortlund EA, Cohen DE, Hagen SJ. Li Y, et al. Among authors: ortlund ea. Nat Commun. 2021 Jun 9;12(1):3493. doi: 10.1038/s41467-021-23595-x. Nat Commun. 2021. PMID: 34108467 Free PMC article.

10

Rapid generation of neutralizing antibody responses in COVID-19 patients.

Suthar MS, Zimmerman M, Kauffman R, Mantus G, Linderman S, Vanderheiden A, Nyhoff L, Davis C, Adekunle S, Affer M, Sherman M, Reynolds S, Verkerke H, Alter DN, Guarner J, Bryksin J, Horwath M, Arthur C, Saakadze N, Smith GH, Edupuganti S, Scherer EM, Hellmeister K, Cheng A, Morales JA, Neish AS, Stowell SR, Frank F, Ortlund E, Anderson E, Menachery V, Rouphael N, Metha A, Stephens DS, Ahmed R, Roback J, Wrammert J. Suthar MS, et al. medRxiv [Preprint]. 2020 May 8:2020.05.03.20084442. doi: 10.1101/2020.05.03.20084442. medRxiv. 2020. Update in: Cell Rep Med. 2020 Jun 23;1(3):100040. doi: 10.1016/j.xcrm.2020.100040 PMID: 32511565 Free PMC article. Updated. Preprint.

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