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Page 1
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling.
Altea-Manzano P, Doglioni G, Liu Y, Cuadros AM, Nolan E, Fernández-García J, Wu Q, Planque M, Laue KJ, Cidre-Aranaz F, Liu XZ, Marin-Bejar O, Van Elsen J, Vermeire I, Broekaert D, Demeyer S, Spotbeen X, Idkowiak J, Montagne A, Demicco M, Alkan HF, Rabas N, Riera-Domingo C, Richard F, Geukens T, De Schepper M, Leduc S, Hatse S, Lambrechts Y, Kay EJ, Lilla S, Alekseenko A, Geldhof V, Boeckx B, de la Calle Arregui C, Floris G, Swinnen JV, Marine JC, Lambrechts D, Pelechano V, Mazzone M, Zanivan S, Cools J, Wildiers H, Baud V, Grünewald TGP, Ben-David U, Desmedt C, Malanchi I, Fendt SM. Altea-Manzano P, et al. Among authors: laue kj. Nat Cancer. 2023 Mar;4(3):344-364. doi: 10.1038/s43018-023-00513-2. Epub 2023 Feb 2. Nat Cancer. 2023. PMID: 36732635 Free PMC article.
Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage.
Zerbib J, Ippolito MR, Eliezer Y, De Feudis G, Reuveni E, Savir Kadmon A, Martin S, Viganò S, Leor G, Berstler J, Muenzner J, Mülleder M, Campagnolo EM, Shulman ED, Chang T, Rubolino C, Laue K, Cohen-Sharir Y, Scorzoni S, Taglietti S, Ratti A, Stossel C, Golan T, Nicassio F, Ruppin E, Ralser M, Vazquez F, Ben-David U, Santaguida S. Zerbib J, et al. Nat Commun. 2024 Sep 9;15(1):7772. doi: 10.1038/s41467-024-52176-x. Nat Commun. 2024. PMID: 39251587 Free PMC article.
CCL2 blockade combined with PD-1/P-selectin immunomodulators impedes breast cancer brain metastasis.
Israeli Dangoor S, Khoury R, Salomon K, Pozzi S, Shahar S, Miari A, Leichtmann-Bardoogo Y, Bar-Hai N, Frommer N, Yeini E, Winkler T, Balint Lahat N, Kamer I, Hadad O, Laue K, Brem H, Hyde TM, Bar J, Barshack I, Ben-David U, Ishay-Ronen D, Maoz BM, Satchi-Fainaro R. Israeli Dangoor S, et al. Brain. 2024 Oct 25:awae347. doi: 10.1093/brain/awae347. Online ahead of print. Brain. 2024. PMID: 39450648
Increased RNA and protein degradation is required for counteracting transcriptional burden and proteotoxic stress in human aneuploid cells.
Ippolito MR, Zerbib J, Eliezer Y, Reuveni E, Vigano S, De Feudis G, Shulman ED, Savir Kadmon A, Slutsky R, Chang T, Campagnolo EM, Taglietti S, Scorzoni S, Gianotti S, Martin S, Muenzner J, Mulleder M, Rozenblum N, Rubolino C, Ben-Yishay T, Laue K, Cohen-Sharir Y, Vigorito I, Nicassio F, Ruppin E, Ralser M, Vazquez F, Santaguida S, Ben-David U. Ippolito MR, et al. Cancer Discov. 2024 Sep 9. doi: 10.1158/2159-8290.CD-23-0309. Online ahead of print. Cancer Discov. 2024. PMID: 39247952