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Gut microbial metabolite hyodeoxycholic acid targets the TLR4/MD2 complex to attenuate inflammation and protect against sepsis.
Li J, Chen Y, Li R, Zhang X, Chen T, Mei F, Liu R, Chen M, Ge Y, Hu H, Wei R, Chen Z, Fan H, Zeng Z, Deng Y, Luo H, Hu S, Cai S, Wu F, Shi N, Wang Z, Zeng Y, Xie M, Jiang Y, Chen Z, Jia W, Chen P. Li J, et al. Among authors: liu r. Mol Ther. 2023 Apr 5;31(4):1017-1032. doi: 10.1016/j.ymthe.2023.01.018. Epub 2023 Jan 24. Mol Ther. 2023. PMID: 36698311 Free PMC article.
A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis.
Gu P, Liu R, Yang Q, Xie L, Wei R, Li J, Mei F, Chen T, Zeng Z, He Y, Zhou H, Peng H, Nandakumar KS, Chu H, Jiang Y, Gong W, Chen Y, Schnabl B, Chen P. Gu P, et al. Among authors: liu r. Cell Mol Immunol. 2023 Oct;20(10):1156-1170. doi: 10.1038/s41423-023-01070-5. Epub 2023 Aug 9. Cell Mol Immunol. 2023. PMID: 37553429 Free PMC article.
Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice.
Li D, Wei R, Zhang X, Gong S, Wan M, Wang F, Li J, Chen M, Liu R, Wan Y, Hong Y, Zeng Z, Gu P, Wang Z, Selva Nandakumar K, Jiang Y, Zhou H, Chen P. Li D, et al. Among authors: liu r. Acta Pharm Sin B. 2024 Jul;14(7):3068-3085. doi: 10.1016/j.apsb.2024.03.025. Epub 2024 Mar 22. Acta Pharm Sin B. 2024. PMID: 39027244 Free PMC article.
Implications of baseline glycemic control by plasma glycated hemoglobin A1c on adverse outcomes in patients with coronary heart disease and type 2 diabetes mellitus: Results from the PROMISE study.
Tang XF, Li QX, Han YL, Wang XZ, Song Y, Zhang Z, Xu JJ, Liu ZY, Chen Y, Zhang YZ, Zhu P, Guo XG, Jiang L, Wang ZF, Liu R, Wang QS, Yao Y, Feng YQ, Zhao XY, Yuan JQ. Tang XF, et al. Among authors: liu r. Heliyon. 2024 Oct 23;10(22):e39748. doi: 10.1016/j.heliyon.2024.e39748. eCollection 2024 Nov 30. Heliyon. 2024. PMID: 39584103 Free PMC article.
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