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Betulinic acid analogs inhibit N- and T-type voltage-gated calcium channels to attenuate nerve-injury associated neuropathic and formalin models of pain.
Calderon-Rivera A, Gomez K, Loya-López S, Wijeratne EMK, Stratton H, Tang C, Duran P, Masterson K, Alsbiei O, Gunatilaka AAL, Khanna R. Calderon-Rivera A, et al. Among authors: alsbiei o. Neurobiol Pain. 2023 Jan 14;13:100116. doi: 10.1016/j.ynpai.2023.100116. eCollection 2023 Jan-Jul. Neurobiol Pain. 2023. PMID: 36687466 Free PMC article.
The natural product argentatin C attenuates postoperative pain via inhibition of voltage-gated sodium and T-type voltage-gated calcium channels.
Duran P, Loya-López S, Ran D, Tang C, Calderon-Rivera A, Gomez K, Stratton HJ, Huang S, Xu YM, Wijeratne EMK, Perez-Miller S, Shan Z, Cai S, Gabrielsen AT, Dorame A, Masterson KA, Alsbiei O, Madura CL, Luo G, Moutal A, Streicher J, Zamponi GW, Gunatilaka AAL, Khanna R. Duran P, et al. Among authors: alsbiei o. Br J Pharmacol. 2023 May;180(9):1267-1285. doi: 10.1111/bph.15974. Epub 2023 Jan 15. Br J Pharmacol. 2023. PMID: 36245395 Free article.
Stereospecific Effects of Benzimidazolonepiperidine Compounds on T-Type Ca2+ Channels and Pain.
Gomez K, Tang C, Tan B, Perez-Miller S, Ran D, Loya S, Calderon-Rivera A, Stratton HJ, Duran P, Masterson KA, Gabrielsen AT, Alsbiei O, Dorame A, Serafini M, Moutal A, Wang J, Khanna R. Gomez K, et al. Among authors: alsbiei o. ACS Chem Neurosci. 2022 Jul 6;13(13):2035-2047. doi: 10.1021/acschemneuro.2c00256. Epub 2022 Jun 7. ACS Chem Neurosci. 2022. PMID: 35671441