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The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L).
Roberts JZ, Holohan C, Sessler T, Fox J, Crawford N, Riley JS, Khawaja H, Majkut J, Evergren E, Humphreys LM, Ferris J, Higgins C, Espona-Fiedler M, Moynagh P, McDade SS, Longley DB. Roberts JZ, et al. Among authors: espona fiedler m. Cell Death Differ. 2020 Sep;27(9):2726-2741. doi: 10.1038/s41418-020-0539-7. Epub 2020 Apr 20. Cell Death Differ. 2020. PMID: 32313199 Free PMC article.
FLIP as a therapeutic target in cancer.
Humphreys L, Espona-Fiedler M, Longley DB. Humphreys L, et al. Among authors: espona fiedler m. FEBS J. 2018 Nov;285(22):4104-4123. doi: 10.1111/febs.14523. Epub 2018 Jun 27. FEBS J. 2018. PMID: 29806737 Free article. Review.