Tillman EJ - Search Results

1

A randomized, double-blind, placebo-controlled phase IIa trial of efruxifermin for patients with compensated NASH cirrhosis.

Harrison SA, Ruane PJ, Freilich B, Neff G, Patil R, Behling C, Hu C, Shringarpure R, de Temple B, Fong E, Tillman EJ, Rolph T, Cheng A, Yale K. Harrison SA, et al. Among authors: tillman ej. JHEP Rep. 2022 Aug 23;5(1):100563. doi: 10.1016/j.jhepr.2022.100563. eCollection 2023 Jan. JHEP Rep. 2022. PMID: 36644237 Free PMC article.

2

Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial.

Harrison SA, Ruane PJ, Freilich BL, Neff G, Patil R, Behling CA, Hu C, Fong E, de Temple B, Tillman EJ, Rolph TP, Cheng A, Yale K. Harrison SA, et al. Among authors: tillman ej. Nat Med. 2021 Jul;27(7):1262-1271. doi: 10.1038/s41591-021-01425-3. Epub 2021 Jul 8. Nat Med. 2021. PMID: 34239138 Clinical Trial.

3

Efruxifermin, a long-acting Fc-fusion FGF21 analogue, reduces body weight gain but does not increase sympathetic tone or urine volume in Sprague Dawley rats.

Tillman EJ, Brock WJ, Rolph T. Tillman EJ, et al. Br J Pharmacol. 2022 Apr;179(7):1384-1394. doi: 10.1111/bph.15725. Epub 2022 Jan 29. Br J Pharmacol. 2022. PMID: 34773249 Free PMC article.

4

FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases.

Tillman EJ, Rolph T. Tillman EJ, et al. Front Endocrinol (Lausanne). 2020 Dec 14;11:601290. doi: 10.3389/fendo.2020.601290. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33381084 Free PMC article. Review.

5

AKR-001, an Fc-FGF21 Analog, Showed Sustained Pharmacodynamic Effects on Insulin Sensitivity and Lipid Metabolism in Type 2 Diabetes Patients.

Kaufman A, Abuqayyas L, Denney WS, Tillman EJ, Rolph T. Kaufman A, et al. Among authors: tillman ej. Cell Rep Med. 2020 Jul 21;1(4):100057. doi: 10.1016/j.xcrm.2020.100057. eCollection 2020 Jul 21. Cell Rep Med. 2020. PMID: 33205064 Free PMC article. Clinical Trial.

6

Safety and Efficacy of Efruxifermin in Combination With a GLP-1 Receptor Agonist in Patients With NASH/MASH and Type 2 Diabetes in a Randomized Phase 2 Study.

Harrison SA, Frias JP, Lucas KJ, Reiss G, Neff G, Bollepalli S, Su Y, Chan D, Tillman EJ, Moulton A, de Temple B, Zari A, Shringarpure R, Rolph T, Cheng A, Yale K. Harrison SA, et al. Among authors: tillman ej. Clin Gastroenterol Hepatol. 2024 Mar 4:S1542-3565(24)00226-X. doi: 10.1016/j.cgh.2024.02.022. Online ahead of print. Clin Gastroenterol Hepatol. 2024. PMID: 38447814 Free article.

7

Safety and efficacy of once-weekly efruxifermin versus placebo in non-alcoholic steatohepatitis (HARMONY): a multicentre, randomised, double-blind, placebo-controlled, phase 2b trial.

Harrison SA, Frias JP, Neff G, Abrams GA, Lucas KJ, Sanchez W, Gogia S, Sheikh MY, Behling C, Bedossa P, Shao L, Chan D, Fong E, de Temple B, Shringarpure R, Tillman EJ, Rolph T, Cheng A, Yale K; HARMONY Study Group. Harrison SA, et al. Among authors: tillman ej. Lancet Gastroenterol Hepatol. 2023 Dec;8(12):1080-1093. doi: 10.1016/S2468-1253(23)00272-8. Epub 2023 Oct 3. Lancet Gastroenterol Hepatol. 2023. PMID: 37802088 Clinical Trial.

8

Noncompetitive immunoassay optimized for pharmacokinetic assessments of biologically active efruxifermin.

Kinne AS, Tillman EJ, Abdeen SJ, Johnson DE, Parmer ES, Hurst JP, de Temple B, Rinker S, Rolph TP, Bowsher RR. Kinne AS, et al. Among authors: tillman ej. J Pharm Biomed Anal. 2023 Aug 5;232:115402. doi: 10.1016/j.jpba.2023.115402. Epub 2023 Apr 18. J Pharm Biomed Anal. 2023. PMID: 37141854 Free article.

9

Global transcriptional regulation of innate immunity by ATF-7 in C. elegans.

Fletcher M, Tillman EJ, Butty VL, Levine SS, Kim DH. Fletcher M, et al. Among authors: tillman ej. PLoS Genet. 2019 Feb 21;15(2):e1007830. doi: 10.1371/journal.pgen.1007830. eCollection 2019 Feb. PLoS Genet. 2019. PMID: 30789901 Free PMC article.

10

Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.

Tillman EJ, Richardson CE, Cattie DJ, Reddy KC, Lehrbach NJ, Droste R, Ruvkun G, Kim DH. Tillman EJ, et al. Genetics. 2018 Dec;210(4):1329-1337. doi: 10.1534/genetics.118.301450. Epub 2018 Oct 4. Genetics. 2018. PMID: 30287474 Free PMC article.

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