O'Geen H - Search Results

1

Transcriptional reprogramming restores UBE3A brain-wide and rescues behavioral phenotypes in an Angelman syndrome mouse model.

O'Geen H, Beitnere U, Garcia MS, Adhikari A, Cameron DL, Fenton TA, Copping NA, Deng P, Lock S, Halmai JANM, Villegas IJ, Liu J, Wang D, Fink KD, Silverman JL, Segal DJ. O'Geen H, et al. Mol Ther. 2023 Apr 5;31(4):1088-1105. doi: 10.1016/j.ymthe.2023.01.013. Epub 2023 Jan 14. Mol Ther. 2023. PMID: 36641623 Free PMC article.

2

A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture.

O'Geen H, Henry IM, Bhakta MS, Meckler JF, Segal DJ. O'Geen H, et al. Nucleic Acids Res. 2015 Mar 31;43(6):3389-404. doi: 10.1093/nar/gkv137. Epub 2015 Feb 20. Nucleic Acids Res. 2015. PMID: 25712100 Free PMC article.

3

How specific is CRISPR/Cas9 really?

O'Geen H, Yu AS, Segal DJ. O'Geen H, et al. Curr Opin Chem Biol. 2015 Dec;29:72-8. doi: 10.1016/j.cbpa.2015.10.001. Epub 2015 Oct 24. Curr Opin Chem Biol. 2015. PMID: 26517564 Free PMC article. Review.

4

Protein Delivery of an Artificial Transcription Factor Restores Widespread Ube3a Expression in an Angelman Syndrome Mouse Brain.

Bailus BJ, Pyles B, McAlister MM, O'Geen H, Lockwood SH, Adams AN, Nguyen JT, Yu A, Berman RF, Segal DJ. Bailus BJ, et al. Mol Ther. 2016 Mar;24(3):548-55. doi: 10.1038/mt.2015.236. Epub 2016 Jan 4. Mol Ther. 2016. PMID: 26727042 Free PMC article.

5

Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells.

Tak YG, Hung Y, Yao L, Grimmer MR, Do A, Bhakta MS, O'Geen H, Segal DJ, Farnham PJ. Tak YG, et al. Nucleic Acids Res. 2016 May 19;44(9):4123-33. doi: 10.1093/nar/gkv1530. Epub 2016 Jan 6. Nucleic Acids Res. 2016. PMID: 26743005 Free PMC article.

6

dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression.

O'Geen H, Ren C, Nicolet CM, Perez AA, Halmai J, Le VM, Mackay JP, Farnham PJ, Segal DJ. O'Geen H, et al. Nucleic Acids Res. 2017 Sep 29;45(17):9901-9916. doi: 10.1093/nar/gkx578. Nucleic Acids Res. 2017. PMID: 28973434 Free PMC article.

7

Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance.

Coggins NB, Stultz J, O'Geen H, Carvajal-Carmona LG, Segal DJ. Coggins NB, et al. Sci Rep. 2017 Nov 8;7(1):15044. doi: 10.1038/s41598-017-15407-4. Sci Rep. 2017. PMID: 29118424 Free PMC article.

8

Purified Protein Delivery to Activate an Epigenetically Silenced Allele in Mouse Brain.

Pyles B, Bailus BJ, O'Geen H, Segal DJ. Pyles B, et al. Methods Mol Biol. 2018;1767:227-239. doi: 10.1007/978-1-4939-7774-1_12. Methods Mol Biol. 2018. PMID: 29524138 Free PMC article.

9

Unexpected binding behaviors of bacterial Argonautes in human cells cast doubts on their use as targetable gene regulators.

O'Geen H, Ren C, Coggins NB, Bates SL, Segal DJ. O'Geen H, et al. PLoS One. 2018 Mar 27;13(3):e0193818. doi: 10.1371/journal.pone.0193818. eCollection 2018. PLoS One. 2018. PMID: 29584750 Free PMC article.

10

Author Correction: Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance.

Coggins NB, Stultz J, O'Geen H, Carvajal-Carmona LG, Segal DJ. Coggins NB, et al. Sci Rep. 2018 Apr 12;8(1):6140. doi: 10.1038/s41598-018-24098-4. Sci Rep. 2018. PMID: 29643450 Free PMC article.

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