The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir.
Jochmans D, Liu C, Donckers K, Stoycheva A, Boland S, Stevens SK, De Vita C, Vanmechelen B, Maes P, Trüeb B, Ebert N, Thiel V, De Jonghe S, Vangeel L, Bardiot D, Jekle A, Blatt LM, Beigelman L, Symons JA, Raboisson P, Chaltin P, Marchand A, Neyts J, Deval J, Vandyck K.
Jochmans D, et al. Among authors: liu c.
mBio. 2023 Feb 28;14(1):e0281522. doi: 10.1128/mbio.02815-22. Epub 2023 Jan 10.
mBio. 2023.
PMID: 36625640
Free PMC article.