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Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy.
Beccari S, Sierra-Torre V, Valero J, Pereira-Iglesias M, García-Zaballa M, Soria FN, De Las Heras-Garcia L, Carretero-Guillen A, Capetillo-Zarate E, Domercq M, Huguet PR, Ramonet D, Osman A, Han W, Dominguez C, Faust TE, Touzani O, Pampliega O, Boya P, Schafer D, Mariño G, Canet-Soulas E, Blomgren K, Plaza-Zabala A, Sierra A. Beccari S, et al. Among authors: sierra a, sierra torre v. Autophagy. 2023 Jul;19(7):1952-1981. doi: 10.1080/15548627.2023.2165313. Epub 2023 Jan 20. Autophagy. 2023. PMID: 36622892 Free PMC article.
Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.
Abiega O, Beccari S, Diaz-Aparicio I, Nadjar A, Layé S, Leyrolle Q, Gómez-Nicola D, Domercq M, Pérez-Samartín A, Sánchez-Zafra V, Paris I, Valero J, Savage JC, Hui CW, Tremblay MÈ, Deudero JJ, Brewster AL, Anderson AE, Zaldumbide L, Galbarriatu L, Marinas A, Vivanco Md, Matute C, Maletic-Savatic M, Encinas JM, Sierra A. Abiega O, et al. Among authors: sierra a. PLoS Biol. 2016 May 26;14(5):e1002466. doi: 10.1371/journal.pbio.1002466. eCollection 2016 May. PLoS Biol. 2016. PMID: 27228556 Free PMC article.
895 results