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Synthetic mRNA rescues very long-chain acyl-CoA dehydrogenase deficiency in patient fibroblasts and a murine model.
Zhao XJ, Mohsen AW, Mihalik S, Solo K, Aliu E, Shi H, Basu S, Kochersperger C, Van't Land C, Karunanidhi A, Coughlan KA, Siddiqui S, Rice LM, Hillier S, Guadagnin E, Giangrande PH, Martini PGV, Vockley J. Zhao XJ, et al. Among authors: giangrande ph. Mol Genet Metab. 2023 Jan;138(1):106982. doi: 10.1016/j.ymgme.2022.106982. Epub 2022 Dec 23. Mol Genet Metab. 2023. PMID: 36580829 Free PMC article.
Amnio acid substitution at position 298 of human glucose-6 phosphatase-α significantly impacts its stability in mammalian cells.
Cao J, Markel A, Hanahoe E, Ketova T, Mihai C, Zalinger Z, Marquardt D, Amato NJ, Cheng YM, Reid DW, Dousis A, Giangrande PH, Schultz JR, Martini PGV, Finn PF. Cao J, et al. Among authors: giangrande ph. Amino Acids. 2023 May;55(5):695-708. doi: 10.1007/s00726-023-03263-8. Epub 2023 Mar 21. Amino Acids. 2023. PMID: 36944899 Free PMC article.
Messenger RNA rescues medium-chain acyl-CoA dehydrogenase deficiency in fibroblasts from patients and a murine model.
Zhao XJ, Mohsen AW, Mihalik S, Solo K, Basu S, Aliu E, Shi H, Kochersberger C, Karunanidhi A, Van't Land C, Coughlan KA, Siddiqui S, Rice LM, Hillier S, Guadagnin E, DeAntonis C, Giangrande PH, Martini PGV, Vockley J. Zhao XJ, et al. Among authors: giangrande ph. Hum Mol Genet. 2023 Jul 4;32(14):2347-2356. doi: 10.1093/hmg/ddad076. Hum Mol Genet. 2023. PMID: 37162351 Free PMC article.
Lipid Nanoparticle mRNA Therapy Improves Survival and Reduces Serum Branched-Chain Amino Acids in Mouse Models of Maple Syrup Urine Disease.
Greig JA, Jennis M, Dandekar A, Chorazeczewski JK, Param N, So M, Nayal M, Bell P, Coughlan K, Choi M, Giangrande PH, Martini PGV, Wilson JM. Greig JA, et al. Among authors: giangrande ph. Hum Gene Ther. 2024 Sep;35(17-18):726-733. doi: 10.1089/hum.2024.047. Epub 2024 Aug 5. Hum Gene Ther. 2024. PMID: 39001827 No abstract available.
Toward the full potential of mRNA therapeutics.
McNamara JO 2nd, Giangrande PH. McNamara JO 2nd, et al. Among authors: giangrande ph. Mol Ther. 2024 Jun 5;32(6):1600-1601. doi: 10.1016/j.ymthe.2024.05.012. Epub 2024 May 23. Mol Ther. 2024. PMID: 38788709 No abstract available.
The Nobel Prize awarded to pioneers of mRNA vaccines.
Herzog RW, Giangrande PH. Herzog RW, et al. Among authors: giangrande ph. Mol Ther. 2023 Nov 1;31(11):3105-3106. doi: 10.1016/j.ymthe.2023.10.006. Epub 2023 Oct 19. Mol Ther. 2023. PMID: 37863063 No abstract available.
Selection of a novel cell-internalizing RNA aptamer specific for CD22 antigen in B cell acute lymphoblastic leukemia.
Ruiz-Ciancio D, Lin LH, Veeramani S, Barros MN, Sanchez D, Di Bartolo AL, Masone D, Giangrande PH, Mestre MB, Thiel WH. Ruiz-Ciancio D, et al. Among authors: giangrande ph. Mol Ther Nucleic Acids. 2023 Jul 28;33:698-712. doi: 10.1016/j.omtn.2023.07.028. eCollection 2023 Sep 12. Mol Ther Nucleic Acids. 2023. PMID: 37662970 Free PMC article.
Monitoring of breast cancer progression via aptamer-based detection of circulating tumor cells in clinical blood samples.
Kolovskaya OS, Zyuzyukina AV, Dassie JP, Zamay GS, Zamay TN, Boyakova NV, Khorzhevskii VA, Kirichenko DA, Lapin IN, Shchugoreva IA, Artyushenko PV, Tomilin FN, Veprintsev DV, Glazyrin YE, Minic Z, Bozhenko VK, Kudinova EA, Kiseleva YY, Krat AV, Slepov EV, Bukatin AS, Zukov RA, Shesternya PA, Berezovski MV, Giangrande PH, Kichkailo AS. Kolovskaya OS, et al. Among authors: giangrande ph. Front Mol Biosci. 2023 Jun 8;10:1184285. doi: 10.3389/fmolb.2023.1184285. eCollection 2023. Front Mol Biosci. 2023. PMID: 37363395 Free PMC article.
Combination of protein and cell internalization SELEX identifies a potential RNA therapeutic and delivery platform to treat EphA2-expressing tumors.
Santana-Viera L, Dassie JP, Rosàs-Lapeña M, Garcia-Monclús S, Chicón-Bosch M, Pérez-Capó M, Pozo LD, Sanchez-Serra S, Almacellas-Rabaiget O, Maqueda-Marcos S, López-Alemany R, Thiel WH, Giangrande PH, Tirado OM. Santana-Viera L, et al. Among authors: giangrande ph. Mol Ther Nucleic Acids. 2023 May 8;32:758-772. doi: 10.1016/j.omtn.2023.05.003. eCollection 2023 Jun 13. Mol Ther Nucleic Acids. 2023. PMID: 37251690 Free PMC article.
74 results