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Microtubule-Stabilizing 1,2,4-Triazolo[1,5-a]pyrimidines as Candidate Therapeutics for Neurodegenerative Disease: Matched Molecular Pair Analyses and Computational Studies Reveal New Structure-Activity Insights.
Alle T, Varricchio C, Yao Y, Lucero B, Nzou G, Demuro S, Muench M, Vuong KD, Oukoloff K, Cornec AS, Francisco KR, Caffrey CR, Lee VM, Smith AB 3rd, Brancale A, Brunden KR, Ballatore C. Alle T, et al. Among authors: brunden kr. J Med Chem. 2023 Jan 12;66(1):435-459. doi: 10.1021/acs.jmedchem.2c01411. Epub 2022 Dec 19. J Med Chem. 2023. PMID: 36534051 Free PMC article.
Abundant copathologies of polyglucosan bodies, frontotemporal lobar degeneration with TDP-43 inclusions and ageing-related tau astrogliopathy in a family with a GBE1 mutation.
Uemura MT, Suh ER, Robinson JL, Brunden KR, Grossman M, Irwin DJ, Lee VM, Trojanowski JQ, Lee EB, Van Deerlin VM. Uemura MT, et al. Among authors: brunden kr. Neuropathol Appl Neurobiol. 2023 Feb;49(1):e12865. doi: 10.1111/nan.12865. Neuropathol Appl Neurobiol. 2023. PMID: 36456471 Free PMC article.
Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolo[1,5- a ]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis.
Monti L, Liu LJ, Varricchio C, Lucero B, Alle T, Yang W, Bem-Shalom I, Gilson M, Brunden KR, Brancale A, Caffrey CR, Ballatore C. Monti L, et al. Among authors: brunden kr. bioRxiv [Preprint]. 2023 Mar 11:2023.03.11.532093. doi: 10.1101/2023.03.11.532093. bioRxiv. 2023. Update in: ChemMedChem. 2023 Oct 17;18(20):e202300193. doi: 10.1002/cmdc.202300193. PMID: 36945407 Free PMC article. Updated. Preprint.
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons.
Xu H, Qiu Q, Hu P, Hoxha K, Jang E, O'Reilly M, Kim C, He Z, Marotta N, Changolkar L, Zhang B, Wu H, Schellenberg GD, Kraemer B, Luk KC, Lee EB, Trojanowski JQ, Brunden KR, Lee VM. Xu H, et al. Among authors: brunden kr. Acta Neuropathol. 2024 Mar 12;147(1):55. doi: 10.1007/s00401-024-02703-3. Acta Neuropathol. 2024. PMID: 38472475 Free PMC article.
Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread.
Jang E, Hoxha K, Mozier D, Insana A, Farber E, Changolkar L, Zhang B, Chio TI, Crowe A, Chen R, Mercken M, Lee EB, Luk KC, Brunden KR, Lee VM, Xu H. Jang E, et al. Among authors: brunden kr. J Neurosci. 2024 Nov 5:e0877242024. doi: 10.1523/JNEUROSCI.0877-24.2024. Online ahead of print. J Neurosci. 2024. PMID: 39500576
A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury.
Zhao X, Zeng W, Xu H, Sun Z, Hu Y, Peng B, McBride JD, Duan J, Deng J, Zhang B, Kim SJ, Zoll B, Saito T, Sasaguri H, Saido TC, Ballatore C, Yao H, Wang Z, Trojanowski JQ, Brunden KR, Lee VM, He Z. Zhao X, et al. Among authors: brunden kr. Sci Transl Med. 2023 Sep 13;15(713):eabo6889. doi: 10.1126/scitranslmed.abo6889. Epub 2023 Sep 13. Sci Transl Med. 2023. PMID: 37703352 Free PMC article.
116 results