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Bypassing evolutionary dead ends and switching the rate-limiting step of a human immunotherapeutic enzyme.
Blazeck J, Karamitros CS, Ford K, Somody C, Qerqez A, Murray K, Burkholder NT, Marshall N, Sivakumar A, Lu WC, Tan B, Lamb C, Tanno Y, Siddiqui MY, Ashoura N, Coma S, Zhang XM, McGovern K, Kumada Y, Zhang YJ, Manfredi M, Johnson KA, D'Arcy S, Stone E, Georgiou G. Blazeck J, et al. Among authors: lu wc. Nat Catal. 2022 Oct;5(10):952-967. doi: 10.1038/s41929-022-00856-6. Epub 2022 Oct 19. Nat Catal. 2022. PMID: 36465553 Free PMC article.
Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme.
Triplett TA, Garrison KC, Marshall N, Donkor M, Blazeck J, Lamb C, Qerqez A, Dekker JD, Tanno Y, Lu WC, Karamitros CS, Ford K, Tan B, Zhang XM, McGovern K, Coma S, Kumada Y, Yamany MS, Sentandreu E, Fromm G, Tiziani S, Schreiber TH, Manfredi M, Ehrlich LIR, Stone E, Georgiou G. Triplett TA, et al. Among authors: lu wc. Nat Biotechnol. 2018 Sep;36(8):758-764. doi: 10.1038/nbt.4180. Epub 2018 Jul 16. Nat Biotechnol. 2018. PMID: 30010674 Free PMC article.
Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.
Lu WC, Saha A, Yan W, Garrison K, Lamb C, Pandey R, Irani S, Lodi A, Lu X, Tiziani S, Zhang YJ, Georgiou G, DiGiovanni J, Stone E. Lu WC, et al. Among authors: lu x. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):13000-13011. doi: 10.1073/pnas.1917362117. Epub 2020 May 20. Proc Natl Acad Sci U S A. 2020. PMID: 32434918 Free PMC article.
Design and selection of a synthetic operon.
Lu WC, Ellington AD. Lu WC, et al. ACS Synth Biol. 2014 Jun 20;3(6):410-5. doi: 10.1021/sb400160m. Epub 2014 Mar 28. ACS Synth Biol. 2014. PMID: 24625092
Prognostic factors and risk-stratification model of recurrent or metastatic head and neck squamous cell carcinoma treated with cetuximab containing regimen.
Yang MH, Chen TH, Wang HM, Hsieh JC, Huang HC, Hsieh MC, Yen CJ, Wu SY, Hua CH, Lien MY, Chang YF, Wang HC, Chien CY, Huang TL, Lu HJ, Lin JC, Wang CC, Liu YC, Chen JP, Lu WC, Yiu CY, Lin CL, Lou PJ, Chu PY. Yang MH, et al. Among authors: lu wc. BMC Cancer. 2024 Oct 5;24(1):1227. doi: 10.1186/s12885-024-12425-0. BMC Cancer. 2024. PMID: 39369189 Free PMC article.
255 results