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Page 1
Chemical modulation of microtubule structure through the laulimalide/peloruside site.
Estévez-Gallego J, Álvarez-Bernad B, Pera B, Wullschleger C, Raes O, Menche D, Martínez JC, Lucena-Agell D, Prota AE, Bonato F, Bargsten K, Cornelus J, Giménez-Abián JF, Northcote P, Steinmetz MO, Kamimura S, Altmann KH, Paterson I, Gago F, Van der Eycken J, Díaz JF, Oliva MÁ. Estévez-Gallego J, et al. Structure. 2023 Jan 5;31(1):88-99.e5. doi: 10.1016/j.str.2022.11.006. Epub 2022 Dec 2. Structure. 2023. PMID: 36462501 Free article.
Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.
Balaguer FA, Mühlethaler T, Estévez-Gallego J, Calvo E, Giménez-Abián JF, Risinger AL, Sorensen EJ, Vanderwal CD, Altmann KH, Mooberry SL, Steinmetz MO, Oliva MÁ, Prota AE, Díaz JF. Balaguer FA, et al. Among authors: estevez gallego j. Int J Mol Sci. 2019 Mar 20;20(6):1392. doi: 10.3390/ijms20061392. Int J Mol Sci. 2019. PMID: 30897704 Free PMC article.
Structural model for differential cap maturation at growing microtubule ends.
Estévez-Gallego J, Josa-Prado F, Ku S, Buey RM, Balaguer FA, Prota AE, Lucena-Agell D, Kamma-Lorger C, Yagi T, Iwamoto H, Duchesne L, Barasoain I, Steinmetz MO, Chrétien D, Kamimura S, Díaz JF, Oliva MA. Estévez-Gallego J, et al. Elife. 2020 Mar 10;9:e50155. doi: 10.7554/eLife.50155. Elife. 2020. PMID: 32151315 Free PMC article.
Taxanes convert regions of perturbed microtubule growth into rescue sites.
Rai A, Liu T, Glauser S, Katrukha EA, Estévez-Gallego J, Rodríguez-García R, Fang WS, Díaz JF, Steinmetz MO, Altmann KH, Kapitein LC, Moores CA, Akhmanova A. Rai A, et al. Among authors: estevez gallego j. Nat Mater. 2020 Mar;19(3):355-365. doi: 10.1038/s41563-019-0546-6. Epub 2019 Dec 9. Nat Mater. 2020. PMID: 31819210
Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions.
Tang Y, Rodríguez-Salarichs J, Zhao Y, Cai P, Estévez-Gallego J, Balaguer-Pérez F, Redondo Horcajo M, Lucena-Agell D, Barasoain I, Díaz JF, Fang WS. Tang Y, et al. Among authors: estevez gallego j. Eur J Med Chem. 2017 Sep 8;137:488-503. doi: 10.1016/j.ejmech.2017.06.001. Epub 2017 Jun 3. Eur J Med Chem. 2017. PMID: 28624703
Structural insight into the stabilization of microtubules by taxanes.
Prota AE, Lucena-Agell D, Ma Y, Estevez-Gallego J, Li S, Bargsten K, Josa-Prado F, Altmann KH, Gaillard N, Kamimura S, Mühlethaler T, Gago F, Oliva MA, Steinmetz MO, Fang WS, Díaz JF. Prota AE, et al. Among authors: estevez gallego j. Elife. 2023 Mar 6;12:e84791. doi: 10.7554/eLife.84791. Elife. 2023. PMID: 36876916 Free PMC article.