McLaughlin JP - Search Results

1

Structure-based design of bitopic ligands for the µ-opioid receptor.

Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S. Faouzi A, et al. Among authors: mclaughlin jp. Nature. 2023 Jan;613(7945):767-774. doi: 10.1038/s41586-022-05588-y. Epub 2022 Nov 30. Nature. 2023. PMID: 36450356 Free PMC article.

2

Unexpected opioid activity profiles of analogues of the novel peptide kappa opioid receptor ligand CJ-15,208.

Aldrich JV, Kulkarni SS, Senadheera SN, Ross NC, Reilley KJ, Eans SO, Ganno ML, Murray TF, McLaughlin JP. Aldrich JV, et al. Among authors: mclaughlin jp. ChemMedChem. 2011 Sep 5;6(9):1739-45. doi: 10.1002/cmdc.201100113. Epub 2011 Jul 14. ChemMedChem. 2011. PMID: 21761566 Free PMC article.

3

The macrocyclic peptide natural product CJ-15,208 is orally active and prevents reinstatement of extinguished cocaine-seeking behavior.

Aldrich JV, Senadheera SN, Ross NC, Ganno ML, Eans SO, McLaughlin JP. Aldrich JV, et al. Among authors: mclaughlin jp. J Nat Prod. 2013 Mar 22;76(3):433-8. doi: 10.1021/np300697k. Epub 2013 Jan 17. J Nat Prod. 2013. PMID: 23327691 Free PMC article.

4

The macrocyclic tetrapeptide [D-Trp]CJ-15,208 produces short-acting κ opioid receptor antagonism in the CNS after oral administration.

Eans SO, Ganno ML, Reilley KJ, Patkar KA, Senadheera SN, Aldrich JV, McLaughlin JP. Eans SO, et al. Among authors: mclaughlin jp. Br J Pharmacol. 2013 May;169(2):426-36. doi: 10.1111/bph.12132. Br J Pharmacol. 2013. PMID: 23425081 Free PMC article.

5

Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors.

Journigan VB, Mésangeau C, Vyas N, Eans SO, Cutler SJ, McLaughlin JP, Mollereau C, McCurdy CR. Journigan VB, et al. Among authors: mclaughlin jp. J Med Chem. 2014 Nov 13;57(21):8903-27. doi: 10.1021/jm500989n. Epub 2014 Oct 21. J Med Chem. 2014. PMID: 25268943 Free PMC article.

6

HIV-1 Tat protein exposure potentiates ethanol reward and reinstates extinguished ethanol-conditioned place preference.

McLaughlin JP, Ganno ML, Eans SO, Mizrachi E, Paris JJ. McLaughlin JP, et al. Curr HIV Res. 2014;12(6):415-23. doi: 10.2174/1570162x1206150311160133. Curr HIV Res. 2014. PMID: 25760047

7

Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors.

Eans SO, Ganno ML, Mizrachi E, Houghten RA, Dooley CT, McLaughlin JP, Nefzi A. Eans SO, et al. Among authors: mclaughlin jp. J Med Chem. 2015 Jun 25;58(12):4905-17. doi: 10.1021/jm501637c. Epub 2015 Jun 4. J Med Chem. 2015. PMID: 25996309

8

Synthesis and characterization of a dual kappa-delta opioid receptor agonist analgesic blocking cocaine reward behavior.

Váradi A, Marrone GF, Eans SO, Ganno ML, Subrath JJ, Le Rouzic V, Hunkele A, Pasternak GW, McLaughlin JP, Majumdar S. Váradi A, et al. Among authors: mclaughlin jp. ACS Chem Neurosci. 2015 Nov 18;6(11):1813-24. doi: 10.1021/acschemneuro.5b00153. Epub 2015 Sep 14. ACS Chem Neurosci. 2015. PMID: 26325040 Free PMC article.

9

Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.

Váradi A, Marrone GF, Palmer TC, Narayan A, Szabó MR, Le Rouzic V, Grinnell SG, Subrath JJ, Warner E, Kalra S, Hunkele A, Pagirsky J, Eans SO, Medina JM, Xu J, Pan YX, Borics A, Pasternak GW, McLaughlin JP, Majumdar S. Váradi A, et al. Among authors: mclaughlin jp. J Med Chem. 2016 Sep 22;59(18):8381-97. doi: 10.1021/acs.jmedchem.6b00748. Epub 2016 Sep 2. J Med Chem. 2016. PMID: 27556704 Free PMC article.

10

Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice.

Spetea M, Eans SO, Ganno ML, Lantero A, Mairegger M, Toll L, Schmidhammer H, McLaughlin JP. Spetea M, et al. Among authors: mclaughlin jp. Br J Pharmacol. 2017 Aug;174(15):2444-2456. doi: 10.1111/bph.13854. Epub 2017 Jun 27. Br J Pharmacol. 2017. PMID: 28494108 Free PMC article.

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