Chen L - Search Results

1

Microcystin-LR-induced nuclear translocation of cGAS promotes mutagenesis in human hepatocytes by impeding homologous recombination repair.

Wang X, Zhu Y, Lu W, Guo X, Chen L, Zhang N, Chen S, Ge C, Xu S. Wang X, et al. Among authors: chen l, chen s. Toxicol Lett. 2023 Jan 15;373:94-104. doi: 10.1016/j.toxlet.2022.11.015. Epub 2022 Nov 23. Toxicol Lett. 2023. PMID: 36435412

2

Design and synthesis of pterostilbene derivatives bearing triazole moiety that might treat DSS-induced colitis in mice through modulation of NF-κB/MAPK signaling pathways.

Chen L, Wang K, Wang L, Wang W, Wang L, Wang W, Li J, Liu X, Wang M, Ruan B. Chen L, et al. Eur J Med Chem. 2024 Jan 5;263:115949. doi: 10.1016/j.ejmech.2023.115949. Epub 2023 Nov 17. Eur J Med Chem. 2024. PMID: 37989058

3

Diarylpentadienone derivatives (curcumin analogues): Synthesis and anti-inflammatory activity.

Wang ZS, Chen LZ, Zhou HP, Liu XH, Chen FH. Wang ZS, et al. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1803-1807. doi: 10.1016/j.bmcl.2017.02.056. Epub 2017 Feb 24. Bioorg Med Chem Lett. 2017. PMID: 28284806

4

Design, synthesis, in vitro and in vivo biological evaluation of pterostilbene derivatives for anti-inflammation therapy.

Chen L, Wang K, Liu X, Wang L, Zou H, Hu S, Zhou L, Li R, Cao S, Ruan B, Cui Q. Chen L, et al. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2315227. doi: 10.1080/14756366.2024.2315227. Epub 2024 Feb 29. J Enzyme Inhib Med Chem. 2024. PMID: 38421003 Free PMC article.

5

Novel Pyrazolo[4,3- d]pyrimidine as Potent and Orally Active Inducible Nitric Oxide Synthase (iNOS) Dimerization Inhibitor with Efficacy in Rheumatoid Arthritis Mouse Model.

Shi JB, Chen LZ, Wang BS, Huang X, Jiao MM, Liu MM, Tang WJ, Liu XH. Shi JB, et al. J Med Chem. 2019 Apr 25;62(8):4013-4031. doi: 10.1021/acs.jmedchem.9b00039. Epub 2019 Apr 5. J Med Chem. 2019. PMID: 30925056

6

Discovery of 4-((E)-3,5-dimethoxy-2-((E)-2-nitrovinyl)styryl)aniline derivatives as potent and orally active NLRP3 inflammasome inhibitors for colitis.

Zhang XX, Diao LZ, Chen LZ, Ma D, Wang YM, Jiang H, Ruan BF, Liu XH. Zhang XX, et al. Eur J Med Chem. 2022 Jun 5;236:114357. doi: 10.1016/j.ejmech.2022.114357. Epub 2022 Apr 7. Eur J Med Chem. 2022. PMID: 35428012

7

Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo.

Chen LZ, Wu J, Li K, Wu QQ, Chen R, Liu XH, Ruan BF. Chen LZ, et al. Eur J Med Chem. 2020 Nov 15;206:112722. doi: 10.1016/j.ejmech.2020.112722. Epub 2020 Aug 14. Eur J Med Chem. 2020. PMID: 32823004

8

Novel resveratrol-based flavonol derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo.

Chen LZ, Yao L, Jiao MM, Shi JB, Tan Y, Ruan BF, Liu XH. Chen LZ, et al. Eur J Med Chem. 2019 Aug 1;175:114-128. doi: 10.1016/j.ejmech.2019.05.004. Epub 2019 May 3. Eur J Med Chem. 2019. PMID: 31077997

9

Synthesis and biological evaluation of myricetin-pentadienone hybrids as potential anti-inflammatory agents in vitro and in vivo.

Liu C, Han X, Yu PJ, Chen LZ, Xue W, Liu XH. Liu C, et al. Bioorg Chem. 2020 Mar;96:103597. doi: 10.1016/j.bioorg.2020.103597. Epub 2020 Jan 29. Bioorg Chem. 2020. PMID: 32028063

10

Discovery of pterostilbene analogs as novel NLRP3 inflammasome inhibitors for potential treatment of DSS-induced colitis in mice.

Ruan B, Rong M, Ming Z, Wang K, Liu X, Deng L, Zhang X, Xu K, Shi C, Gao T, Liu X, Chen L. Ruan B, et al. Among authors: chen l. Bioorg Chem. 2023 Apr;133:106429. doi: 10.1016/j.bioorg.2023.106429. Epub 2023 Feb 18. Bioorg Chem. 2023. PMID: 36841048

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