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Morphology and gene expression profiling provide complementary information for mapping cell state.
Cell Syst. 2022 Nov 16;13(11):911-923.e9. doi: 10.1016/j.cels.2022.10.001. Epub 2022 Oct 28.
Cell Syst. 2022.
PMID: 36395727
Free PMC article.
Discovering metabolic disease gene interactions by correlated effects on cellular morphology.
Jiao Y, Ahmed U, Sim MFM, Bejar A, Zhang X, Talukder MMU, Rice R, Flannick J, Podgornaia AI, Reilly DF, Engreitz JM, Kost-Alimova M, Hartland K, Mercader JM, Georges S, Wagh V, Tadin-Strapps M, Doench JG, Edwardson JM, Rochford JJ, Rosen ED, Majithia AR.
Jiao Y, et al. Among authors: hartland k.
Mol Metab. 2019 Jun;24:108-119. doi: 10.1016/j.molmet.2019.03.001. Epub 2019 Mar 13.
Mol Metab. 2019.
PMID: 30940487
Free PMC article.
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A small-molecule inducer of PDX1 expression identified by high-throughput screening.
Yuan Y, Hartland K, Boskovic Z, Wang Y, Walpita D, Lysy PA, Zhong C, Young DW, Kim YK, Tolliday NJ, Sokal EM, Schreiber SL, Wagner BK.
Yuan Y, et al. Among authors: hartland k.
Chem Biol. 2013 Dec 19;20(12):1513-22. doi: 10.1016/j.chembiol.2013.10.013. Epub 2013 Nov 27.
Chem Biol. 2013.
PMID: 24290880
Free PMC article.
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Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy.
Dvela-Levitt M, Kost-Alimova M, Emani M, Kohnert E, Thompson R, Sidhom EH, Rivadeneira A, Sahakian N, Roignot J, Papagregoriou G, Montesinos MS, Clark AR, McKinney D, Gutierrez J, Roth M, Ronco L, Elonga E, Carter TA, Gnirke A, Melanson M, Hartland K, Wieder N, Hsu JC, Deltas C, Hughey R, Bleyer AJ, Kmoch S, Živná M, Barešova V, Kota S, Schlondorff J, Heiman M, Alper SL, Wagner F, Weins A, Golub TR, Lander ES, Greka A.
Dvela-Levitt M, et al. Among authors: hartland k.
Cell. 2019 Jul 25;178(3):521-535.e23. doi: 10.1016/j.cell.2019.07.002.
Cell. 2019.
PMID: 31348885
Free article.
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A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives.
Li Y, Wei L, Meinsohn MC, Suliman R, Chauvin M, Berstler J, Hartland K, Jensen MM, Sicher NA, Nagykery N, Donahoe PK, Pepin D.
Li Y, et al. Among authors: hartland k.
Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2122512119. doi: 10.1073/pnas.2122512119. Epub 2022 Apr 5.
Proc Natl Acad Sci U S A. 2022.
PMID: 35380904
Free PMC article.
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High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling.
Hartland K, Pu J, Palmer M, Dandapani S, Moquist PN, Munoz B, DiDone L, Schreiber SL, Krysan DJ.
Hartland K, et al.
ACS Infect Dis. 2016 Jan 8;2(1):93-102. doi: 10.1021/acsinfecdis.5b00111. Epub 2015 Nov 6.
ACS Infect Dis. 2016.
PMID: 26807437
Free PMC article.
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