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Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.
Saaoud F, Liu L, Xu K, Cueto R, Shao Y, Lu Y, Sun Y, Snyder NW, Wu S, Yang L, Zhou Y, Williams DL, Li C, Martinez L, Vazquez-Padron RI, Zhao H, Jiang X, Wang H, Yang X. Saaoud F, et al. Among authors: xu k. JCI Insight. 2023 Jan 10;8(1):e158183. doi: 10.1172/jci.insight.158183. JCI Insight. 2023. PMID: 36394956 Free PMC article.
Mitochondrial ROS, uncoupled from ATP synthesis, determine endothelial activation for both physiological recruitment of patrolling cells and pathological recruitment of inflammatory cells.
Li X, Fang P, Yang WY, Chan K, Lavallee M, Xu K, Gao T, Wang H, Yang X. Li X, et al. Among authors: xu k. Can J Physiol Pharmacol. 2017 Mar;95(3):247-252. doi: 10.1139/cjpp-2016-0515. Epub 2016 Nov 5. Can J Physiol Pharmacol. 2017. PMID: 27925481 Free PMC article. Review.
Co-signaling receptors regulate T-cell plasticity and immune tolerance.
Shen H, Wu N, Nanayakkara G, Fu H, Yang Q, Yang WY, Li A, Sun Y, Drummer Iv C, Johnson C, Shao Y, Wang L, Xu K, Hu W, Chan M, Tam V, Choi ET, Wang H, Yang X. Shen H, et al. Among authors: xu k. Front Biosci (Landmark Ed). 2019 Jan 1;24(1):96-132. doi: 10.2741/4710. Front Biosci (Landmark Ed). 2019. PMID: 30468648 Free PMC article.
Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors.
Lai B, Wang J, Fagenson A, Sun Y, Saredy J, Lu Y, Nanayakkara G, Yang WY, Yu D, Shao Y, Drummer C 4th, Johnson C, Saaoud F, Zhang R, Yang Q, Xu K, Mastascusa K, Cueto R, Fu H, Wu S, Sun L, Zhu P, Qin X, Yu J, Fan D, Shen YH, Sun J, Rogers T, Choi ET, Wang H, Yang X. Lai B, et al. Among authors: xu k. Front Immunol. 2019 Nov 14;10:2612. doi: 10.3389/fimmu.2019.02612. eCollection 2019. Front Immunol. 2019. PMID: 31824480 Free PMC article.
End-stage renal disease is different from chronic kidney disease in upregulating ROS-modulated proinflammatory secretome in PBMCs - A novel multiple-hit model for disease progression.
Zhang R, Saredy J, Shao Y, Yao T, Liu L, Saaoud F, Yang WY, Sun Y, Johnson C, Drummer C 4th, Fu H, Lu Y, Xu K, Liu M, Wang J, Cutler E, Yu D, Jiang X, Li Y, Li R, Wang L, Choi ET, Wang H, Yang X. Zhang R, et al. Among authors: xu k. Redox Biol. 2020 Jul;34:101460. doi: 10.1016/j.redox.2020.101460. Epub 2020 Feb 20. Redox Biol. 2020. PMID: 32179051 Free PMC article.
Vascular Endothelial Cells and Innate Immunity.
Shao Y, Saredy J, Yang WY, Sun Y, Lu Y, Saaoud F, Drummer C 4th, Johnson C, Xu K, Jiang X, Wang H, Yang X. Shao Y, et al. Among authors: xu k. Arterioscler Thromb Vasc Biol. 2020 Jun;40(6):e138-e152. doi: 10.1161/ATVBAHA.120.314330. Epub 2020 May 27. Arterioscler Thromb Vasc Biol. 2020. PMID: 32459541 Free PMC article. Review.
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