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Combined targeting of soluble latent TGF-ß and a solid tumor-associated antigen with adapter CAR T cells.
Werchau N, Kotter B, Criado-Moronati E, Gosselink A, Cordes N, Lock D, Lennartz S, Kolbe C, Winter N, Teppert K, Engert F, Webster B, Mittelstaet J, Schaefer D, Mallmann P, Mallmann MR, Ratiu D, Assenmacher M, Schaser T, von Bergwelt-Baildon M, Abramowski P, Kaiser AD. Werchau N, et al. Among authors: mittelstaet j. Oncoimmunology. 2022 Nov 11;11(1):2140534. doi: 10.1080/2162402X.2022.2140534. eCollection 2022. Oncoimmunology. 2022. PMID: 36387056 Free PMC article.
Titratable Pharmacological Regulation of CAR T Cells Using Zinc Finger-Based Transcription Factors.
Kotter B, Engert F, Krueger W, Roy A, Rawashdeh WA, Cordes N, Drees B, Webster B, Werchau N, Lock D, Dapa S, Schneider D, Ludwig S, Rossig C, Assenmacher M, Mittelstaet J, Kaiser AD. Kotter B, et al. Among authors: mittelstaet j. Cancers (Basel). 2021 Sep 22;13(19):4741. doi: 10.3390/cancers13194741. Cancers (Basel). 2021. PMID: 34638227 Free PMC article.
CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1.
Kantari-Mimoun C, Barrin S, Vimeux L, Haghiri S, Gervais C, Joaquina S, Mittelstaet J, Mockel-Tenbrinck N, Kinkhabwala A, Damotte D, Lupo A, Sibony M, Alifano M, Dondi E, Bercovici N, Trautmann A, Kaiser AD, Donnadieu E. Kantari-Mimoun C, et al. Among authors: mittelstaet j. Cancer Immunol Res. 2021 Dec;9(12):1425-1438. doi: 10.1158/2326-6066.CIR-20-0837. Epub 2021 Oct 22. Cancer Immunol Res. 2021. PMID: 34686489
Novel adapter CAR-T cell technology for precisely controllable multiplex cancer targeting.
Seitz CM, Mittelstaet J, Atar D, Hau J, Reiter S, Illi C, Kieble V, Engert F, Drees B, Bender G, Krahl AC, Knopf P, Schroeder S, Paulsen N, Rokhvarguer A, Scheuermann S, Rapp E, Mast AS, Rabsteyn A, Schleicher S, Grote S, Schilbach K, Kneilling M, Pichler B, Lock D, Kotter B, Dapa S, Miltenyi S, Kaiser A, Lang P, Handgretinger R, Schlegel P. Seitz CM, et al. Among authors: mittelstaet j. Oncoimmunology. 2021 Dec 2;10(1):2003532. doi: 10.1080/2162402X.2021.2003532. eCollection 2021. Oncoimmunology. 2021. PMID: 35686214 Free PMC article.
Adapter CAR T cells to counteract T-cell exhaustion and enable flexible targeting in AML.
Nixdorf D, Sponheimer M, Berghammer D, Engert F, Bader U, Philipp N, Kazerani M, Straub T, Rohrbacher L, Wange L, Dapa S, Atar D, Seitz CM, Brandstetter K, Linder A, von Bergwelt M, Leonhardt H, Mittelstaet J, Kaiser A, Bücklein V, Subklewe M. Nixdorf D, et al. Among authors: mittelstaet j. Leukemia. 2023 Jun;37(6):1298-1310. doi: 10.1038/s41375-023-01905-0. Epub 2023 Apr 27. Leukemia. 2023. PMID: 37106163 Free PMC article.
Rational combinatorial targeting by adapter CAR-T-cells (AdCAR-T) prevents antigen escape in acute myeloid leukemia.
Atar D, Ruoff L, Mast AS, Krost S, Moustafa-Oglou M, Scheuermann S, Kristmann B, Feige M, Canak A, Wolsing K, Schlager L, Schilbach K, Zekri L, Ebinger M, Nixdorf D, Subklewe M, Schulte J, Lengerke C, Jeremias I, Werchau N, Mittelstaet J, Lang P, Handgretinger R, Schlegel P, Seitz CM. Atar D, et al. Among authors: mittelstaet j. Leukemia. 2024 Oct;38(10):2183-2195. doi: 10.1038/s41375-024-02351-2. Epub 2024 Aug 3. Leukemia. 2024. PMID: 39095503 Free PMC article.
15 results