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Acetaldehyde dehydrogenase 2 (ALDH2) deficiency exacerbates pressure overload-induced cardiac dysfunction by inhibiting Beclin-1 dependent autophagy pathway.
Shen C, Wang C, Fan F, Yang Z, Cao Q, Liu X, Sun X, Zhao X, Wang P, Ma X, Zhu H, Dong Z, Zou Y, Hu K, Sun A, Ge J. Shen C, et al. Among authors: sun a, sun x. Biochim Biophys Acta. 2015 Feb;1852(2):310-8. doi: 10.1016/j.bbadis.2014.07.014. Epub 2014 Jul 30. Biochim Biophys Acta. 2015. PMID: 25086229 Free article.
Mitochondrial Aldehyde Dehydrogenase 2 Regulates Revascularization in Chronic Ischemia: Potential Impact on the Development of Coronary Collateral Circulation.
Liu X, Sun X, Liao H, Dong Z, Zhao J, Zhu H, Wang P, Shen L, Xu L, Ma X, Shen C, Fan F, Wang C, Hu K, Zou Y, Ge J, Ren J, Sun A. Liu X, et al. Among authors: sun a, sun x. Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2196-206. doi: 10.1161/ATVBAHA.115.306012. Epub 2015 Aug 27. Arterioscler Thromb Vasc Biol. 2015. PMID: 26315408
Aldehyde dehydrogenase 2 deficiency negates chronic low-to-moderate alcohol consumption-induced cardioprotecion possibly via ROS-dependent apoptosis and RIP1/RIP3/MLKL-mediated necroptosis.
Shen C, Wang C, Han S, Wang Z, Dong Z, Zhao X, Wang P, Zhu H, Sun X, Ma X, Zhu H, Zou Y, Hu K, Ge J, Sun A. Shen C, et al. Among authors: sun a, sun x. Biochim Biophys Acta Mol Basis Dis. 2017 Aug;1863(8):1912-1918. doi: 10.1016/j.bbadis.2016.11.016. Epub 2016 Nov 11. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 27840306 Free article.
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