Yu X - Search Results

1

Applications of covalent chemistry in targeted protein degradation.

Lu D, Yu X, Lin H, Cheng R, Monroy EY, Qi X, Wang MC, Wang J. Lu D, et al. Among authors: yu x. Chem Soc Rev. 2022 Nov 14;51(22):9243-9261. doi: 10.1039/d2cs00362g. Chem Soc Rev. 2022. PMID: 36285735 Free PMC article. Review.

2

Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry.

Guo WH, Qi X, Yu X, Liu Y, Chung CI, Bai F, Lin X, Lu D, Wang L, Chen J, Su LH, Nomie KJ, Li F, Wang MC, Shu X, Onuchic JN, Woyach JA, Wang ML, Wang J. Guo WH, et al. Among authors: yu x. Nat Commun. 2020 Aug 26;11(1):4268. doi: 10.1038/s41467-020-17997-6. Nat Commun. 2020. PMID: 32848159 Free PMC article.

3

Discovery of a potent BTK and IKZF1/3 triple degrader through reversible covalent BTK PROTAC development.

Yu X, Guo WH, Lin H, Cheng R, Monroy EY, Jin F, Ding L, Lu D, Qi X, Wang MC, Wang J. Yu X, et al. Curr Res Chem Biol. 2022;2:100029. doi: 10.1016/j.crchbi.2022.100029. Epub 2022 May 17. Curr Res Chem Biol. 2022. PMID: 36712232 Free PMC article.

4

Quantitative measurement of PROTAC intracellular accumulation.

Yu X, Wang J. Yu X, et al. Methods Enzymol. 2023;681:189-214. doi: 10.1016/bs.mie.2022.11.001. Epub 2022 Dec 19. Methods Enzymol. 2023. PMID: 36764757 Free PMC article.

5

Quantification of glutathione with high throughput live-cell imaging.

Qi X, Chen J, Jiang X, Lu D, Yu X, Lin H, Monroy EY, Wang MC, Wang J. Qi X, et al. Among authors: yu x. bioRxiv [Preprint]. 2023 Jul 12:2023.07.11.548586. doi: 10.1101/2023.07.11.548586. bioRxiv. 2023. PMID: 37503234 Free PMC article. Preprint.

6

Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy.

Lu D, Chen J, Qin L, Bijou I, Yi P, Li F, Song X, MacKenzie KR, Yu X, Yang B, Roy Chowdhury S, Korp JD, O'Malley BW, Lonard DM, Wang J. Lu D, et al. Among authors: yu x. J Med Chem. 2024 Apr 11;67(7):5333-5350. doi: 10.1021/acs.jmedchem.3c01596. Epub 2024 Mar 29. J Med Chem. 2024. PMID: 38551814 Free PMC article.

7

Development of a First-in-Class RIPK1 Degrader to Enhance Antitumor Immunity.

Yu X, Lu D, Qi X, Lin H, Holloman BL, Jin F, Xu L, Ding L, Peng W, Wang MC, Chen X, Wang J. Yu X, et al. bioRxiv [Preprint]. 2024 Mar 29:2024.03.25.586133. doi: 10.1101/2024.03.25.586133. bioRxiv. 2024. PMID: 38590362 Free PMC article. Preprint.

8

Development of a First-in-Class RIPK1 Degrader to Enhance Antitumor Immunity.

Wang J, Lu D, Yu X, Qi X, Lin H, Holloman BL, Jin F, Xu L, Ding L, Peng W, Wang M, Chen X. Wang J, et al. Among authors: yu x. Res Sq [Preprint]. 2024 Apr 8:rs.3.rs-4156736. doi: 10.21203/rs.3.rs-4156736/v1. Res Sq. 2024. PMID: 38659866 Free PMC article. Preprint.

9

Development of Biochemical and Cellular Probes to Study RIPK1 Target Engagement.

Yu X, Lin H, Li F, Wang J, Lu D. Yu X, et al. ACS Med Chem Lett. 2024 May 10;15(6):906-916. doi: 10.1021/acsmedchemlett.4c00104. eCollection 2024 Jun 13. ACS Med Chem Lett. 2024. PMID: 38894934

10

Chemical Induction of Longevity-Promoting Colanic Acid in the Host's Microbiota.

Hu G, Cooke MB, Wen AX, Yu X, Wang J, Herman C, Wang MC. Hu G, et al. Among authors: yu x. bioRxiv [Preprint]. 2024 Jul 24:2024.07.23.604802. doi: 10.1101/2024.07.23.604802. bioRxiv. 2024. PMID: 39211270 Free PMC article. Preprint.

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