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PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma.
Sharma G, Ojha R, Noguera-Ortega E, Rebecca VW, Attanasio J, Liu S, Piao S, Lee JJ, Nicastri MC, Harper SL, Ronghe A, Jain V, Winkler JD, Speicher DW, Mastio J, Gimotty PA, Xu X, Wherry EJ, Gabrilovich DI, Amaravadi RK. Sharma G, et al. Among authors: speicher dw. JCI Insight. 2022 Oct 24;7(20):e165688. doi: 10.1172/jci.insight.165688. JCI Insight. 2022. PMID: 36278493 Free PMC article. No abstract available.
Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition.
Jain V, Harper SL, Versace AM, Fingerman D, Brown GS, Bhardwaj M, Crissey MAS, Goldman AR, Ruthel G, Liu Q, Zivkovic A, Stark H, Herlyn M, Gimotty PA, Speicher DW, Amaravadi RK. Jain V, et al. Among authors: speicher dw. Cancer Discov. 2023 Feb 6;13(2):454-473. doi: 10.1158/2159-8290.CD-22-0535. Cancer Discov. 2023. PMID: 36331284 Free PMC article.
Lysosomal lipid peroxidation regulates tumor immunity.
Bhardwaj M, Lee JJ, Versace AM, Harper SL, Goldman AR, Crissey MAS, Jain V, Singh MP, Vernon M, Aplin AE, Lee S, Morita M, Winkler JD, Liu Q, Speicher DW, Amaravadi RK. Bhardwaj M, et al. Among authors: speicher dw. J Clin Invest. 2023 Apr 17;133(8):e164596. doi: 10.1172/JCI164596. J Clin Invest. 2023. PMID: 36795483 Free PMC article.
Age-Related Increases in IGFBP2 Increase Melanoma Cell Invasion and Lipid Synthesis.
Alicea GM, Patel P, Portuallo ME, Fane ME, Wei M, Chhabra Y, Dixit A, Carey AE, Wang V, Rocha MR, Behera R, Speicher DW, Tang HY, Kossenkov AV, Rebecca VW, Wirtz D, Weeraratna AT. Alicea GM, et al. Among authors: speicher dw. Cancer Res Commun. 2024 Aug 1;4(8):1908-1918. doi: 10.1158/2767-9764.CRC-23-0176. Cancer Res Commun. 2024. PMID: 39007351 Free PMC article.
Multiplexed serum biomarkers to discriminate nonviable and ectopic pregnancy.
Barnhart KT, Bollig KJ, Senapati S, Takacs P, Robins JC, Haisenleder DJ, Beer LA, Savaris RF, Koelper NC, Speicher DW, Chittams J, Bao J, Wen Z, Feng Y, Kim M, Mumford S, Shen L, Gimotty P. Barnhart KT, et al. Among authors: speicher dw. Fertil Steril. 2024 Sep;122(3):482-493. doi: 10.1016/j.fertnstert.2024.04.028. Epub 2024 Apr 26. Fertil Steril. 2024. PMID: 38677710
TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation.
Hao X, Zhao B, Towers M, Liao L, Monteiro EL, Xu X, Freeman C, Peng H, Tang HY, Havas A, Kossenkov AV, Berger SL, Adams PD, Speicher DW, Schultz D, Marmorstein R, Zaret KS, Zhang R. Hao X, et al. Among authors: speicher dw. Nat Aging. 2024 Feb;4(2):185-197. doi: 10.1038/s43587-023-00564-1. Epub 2024 Jan 24. Nat Aging. 2024. PMID: 38267705 Free PMC article.
Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression.
Yeon M, Bertolini I, Agarwal E, Ghosh JC, Tang HY, Speicher DW, Keeney F, Sossey-Alaoui K, Pluskota E, Bialkowska K, Plow EF, Languino LR, Skordalakes E, Caino MC, Altieri DC. Yeon M, et al. Among authors: speicher dw. J Biol Chem. 2023 Jun;299(6):104774. doi: 10.1016/j.jbc.2023.104774. Epub 2023 May 2. J Biol Chem. 2023. PMID: 37142218 Free PMC article.
256 results