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Page 1
Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma.
Keller KM, Eleveld TF, Schild L, van den Handel K, van den Boogaard M, Amo-Addae V, Eising S, Ober K, Koopmans B, Looijenga L, Tytgat GAM, Ylstra B, Molenaar JJ, Dolman MEM, van Hooff SR. Keller KM, et al. Among authors: eleveld tf. Front Oncol. 2022 Sep 27;12:929123. doi: 10.3389/fonc.2022.929123. eCollection 2022. Front Oncol. 2022. PMID: 36237330 Free PMC article.
Engineering large-scale chromosomal deletions by CRISPR-Cas9.
Eleveld TF, Bakali C, Eijk PP, Stathi P, Vriend LE, Poddighe PJ, Ylstra B. Eleveld TF, et al. Nucleic Acids Res. 2021 Dec 2;49(21):12007-12016. doi: 10.1093/nar/gkab557. Nucleic Acids Res. 2021. PMID: 34230973 Free PMC article.
Chromosome 3p25.3 Gain Is Associated With Cisplatin Resistance and Is an Independent Predictor of Poor Outcome in Male Malignant Germ Cell Tumors.
Timmerman DM, Eleveld TF, Sriram S, Dorssers LCJ, Gillis AJM, Schmidtova S, Kalavska K, van de Werken HJG, Oing C, Honecker F, Mego M, Looijenga LHJ. Timmerman DM, et al. Among authors: eleveld tf. J Clin Oncol. 2022 Sep 10;40(26):3077-3087. doi: 10.1200/JCO.21.02809. Epub 2022 Apr 20. J Clin Oncol. 2022. PMID: 35442716 Free PMC article.
Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations.
Eleveld TF, Oldridge DA, Bernard V, Koster J, Colmet Daage L, Diskin SJ, Schild L, Bentahar NB, Bellini A, Chicard M, Lapouble E, Combaret V, Legoix-Né P, Michon J, Pugh TJ, Hart LS, Rader J, Attiyeh EF, Wei JS, Zhang S, Naranjo A, Gastier-Foster JM, Hogarty MD, Asgharzadeh S, Smith MA, Guidry Auvil JM, Watkins TB, Zwijnenburg DA, Ebus ME, van Sluis P, Hakkert A, van Wezel E, van der Schoot CE, Westerhout EM, Schulte JH, Tytgat GA, Dolman ME, Janoueix-Lerosey I, Gerhard DS, Caron HN, Delattre O, Khan J, Versteeg R, Schleiermacher G, Molenaar JJ, Maris JM. Eleveld TF, et al. Nat Genet. 2015 Aug;47(8):864-71. doi: 10.1038/ng.3333. Epub 2015 Jun 29. Nat Genet. 2015. PMID: 26121087 Free PMC article.
Systematic target actionability reviews of preclinical proof-of-concept papers to match targeted drugs to paediatric cancers.
Schubert NA, Lowery CD, Bergthold G, Koster J, Eleveld TF, Rodríguez A, Jones DTW, Vassal G, Stancato LF, Pfister SM, Caron HN, Molenaar JJ. Schubert NA, et al. Among authors: eleveld tf. Eur J Cancer. 2020 May;130:168-181. doi: 10.1016/j.ejca.2020.01.027. Epub 2020 Mar 27. Eur J Cancer. 2020. PMID: 32224415 Free PMC article. Review.
Feeder-free culture of human pluripotent stem cells drives MDM4-mediated gain of chromosome 1q.
Stavish D, Price CJ, Gelezauskaite G, Alsehli H, Leonhard KA, Taapken SM, McIntire EM, Laing O, James BM, Riley JJ, Zerbib J, Baker D, Harding AL, Jestice LH, Eleveld TF, Gillis AJM, Hillenius S, Looijenga LHJ, Gokhale PJ, Ben-David U, Ludwig TE, Barbaric I. Stavish D, et al. Among authors: eleveld tf. Stem Cell Reports. 2024 Aug 13;19(8):1217-1232. doi: 10.1016/j.stemcr.2024.06.003. Epub 2024 Jul 3. Stem Cell Reports. 2024. PMID: 38964325 Free PMC article.
MEK inhibition causes BIM stabilization and increased sensitivity to BCL-2 family member inhibitors in RAS-MAPK-mutated neuroblastoma.
Eleveld TF, Vernooij L, Schild L, Koopmans B, Alles LK, Ebus ME, Dandis R, van Tinteren H, Caron HN, Koster J, van Noesel MM, Tytgat GAM, Eising S, Versteeg R, Dolman MEM, Molenaar JJ. Eleveld TF, et al. Front Oncol. 2023 Feb 21;13:1130034. doi: 10.3389/fonc.2023.1130034. eCollection 2023. Front Oncol. 2023. PMID: 36895472 Free PMC article.