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A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.
Nat Commun. 2022 Oct 10;13(1):5969. doi: 10.1038/s41467-022-33430-6.
Nat Commun. 2022.
PMID: 36216795
Free PMC article.
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity.
Imaide S, Riching KM, Makukhin N, Vetma V, Whitworth C, Hughes SJ, Trainor N, Mahan SD, Murphy N, Cowan AD, Chan KH, Craigon C, Testa A, Maniaci C, Urh M, Daniels DL, Ciulli A.
Imaide S, et al. Among authors: vetma v.
Nat Chem Biol. 2021 Nov;17(11):1157-1167. doi: 10.1038/s41589-021-00878-4. Epub 2021 Oct 21.
Nat Chem Biol. 2021.
PMID: 34675414
Free PMC article.
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Targeting cancer with small-molecule pan-KRAS degraders.
Popow J, Farnaby W, Gollner A, Kofink C, Fischer G, Wurm M, Zollman D, Wijaya A, Mischerikow N, Hasenoehrl C, Prokofeva P, Arnhof H, Arce-Solano S, Bell S, Boeck G, Diers E, Frost AB, Goodwin-Tindall J, Karolyi-Oezguer J, Khan S, Klawatsch T, Koegl M, Kousek R, Kratochvil B, Kropatsch K, Lauber AA, McLennan R, Olt S, Peter D, Petermann O, Roessler V, Stolt-Bergner P, Strack P, Strauss E, Trainor N, Vetma V, Whitworth C, Zhong S, Quant J, Weinstabl H, Kuster B, Ettmayer P, Ciulli A.
Popow J, et al. Among authors: vetma v.
Science. 2024 Sep 20;385(6715):1338-1347. doi: 10.1126/science.adm8684. Epub 2024 Sep 19.
Science. 2024.
PMID: 39298590
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Confounding Factors in Targeted Degradation of Short-Lived Proteins.
Vetma V, Perez LC, Eliaš J, Stingu A, Kombara A, Gmaschitz T, Braun N, Ciftci T, Dahmann G, Diers E, Gerstberger T, Greb P, Kidd G, Kofink C, Puoti I, Spiteri V, Trainor N, Weinstabl H, Westermaier Y, Whitworth C, Ciulli A, Farnaby W, McAulay K, Frost AB, Chessum N, Koegl M.
Vetma V, et al.
ACS Chem Biol. 2024 Jul 19;19(7):1484-1494. doi: 10.1021/acschembio.4c00152. Epub 2024 Jul 3.
ACS Chem Biol. 2024.
PMID: 38958654
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Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism.
Vetma V, Guttà C, Peters N, Praetorius C, Hutt M, Seifert O, Meier F, Kontermann R, Kulms D, Rehm M.
Vetma V, et al.
Cell Death Differ. 2020 Aug;27(8):2417-2432. doi: 10.1038/s41418-020-0512-5. Epub 2020 Feb 21.
Cell Death Differ. 2020.
PMID: 32081986
Free PMC article.
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Optimization of an ex vivo gene transfer to the hamstrings tendons muscle remnants: potential for genetic enhancement of bone healing.
Rod E, Matić I, Antunović M, Vetma V, Pavičić I, Hudetz D, Marijanović I, Primorac D, Ivković A.
Rod E, et al. Among authors: vetma v.
Croat Med J. 2019 Jun 13;60(3):201-211. doi: 10.3325/cmj.2019.60.201.
Croat Med J. 2019.
PMID: 31187947
Free PMC article.
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Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma.
Rožanc J, Sakellaropoulos T, Antoranz A, Guttà C, Podder B, Vetma V, Rufo N, Agostinis P, Pliaka V, Sauter T, Kulms D, Rehm M, Alexopoulos LG.
Rožanc J, et al. Among authors: vetma v.
Cell Death Differ. 2019 Aug;26(8):1365-1378. doi: 10.1038/s41418-018-0210-8. Epub 2018 Oct 15.
Cell Death Differ. 2019.
PMID: 30323272
Free PMC article.
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Examining the In Vitro Efficacy of the IAP Antagonist Birinapant as a Single Agent or in Combination With Dacarbazine to Induce Melanoma Cell Death.
Vetma V, Rožanc J, Charles EM, Hellwig CT, Alexopoulos LG, Rehm M.
Vetma V, et al.
Oncol Res. 2017 Nov 2;25(9):1489-1494. doi: 10.3727/096504017X14897145996933. Epub 2017 Mar 23.
Oncol Res. 2017.
PMID: 28337955
Free PMC article.
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