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A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo.
Nat Commun. 2022 Oct 10;13(1):5969. doi: 10.1038/s41467-022-33430-6.
Nat Commun. 2022.
PMID: 36216795
Free PMC article.
Targeted Synthesis of Complex Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2-p53 Inhibitors.
Gollner A, Weinstabl H, Fuchs JE, Rudolph D, Garavel G, Hofbauer KS, Karolyi-Oezguer J, Gmaschitz G, Hela W, Kerres N, Grondal E, Werni P, Ramharter J, Broeker J, McConnell DB.
Gollner A, et al. Among authors: garavel g.
ChemMedChem. 2019 Jan 8;14(1):88-93. doi: 10.1002/cmdc.201800617. Epub 2018 Dec 11.
ChemMedChem. 2019.
PMID: 30458062
Free PMC article.
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Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis.
Weinstabl H, Treu M, Rinnenthal J, Zahn SK, Ettmayer P, Bader G, Dahmann G, Kessler D, Rumpel K, Mischerikow N, Savarese F, Gerstberger T, Mayer M, Zoephel A, Schnitzer R, Sommergruber W, Martinelli P, Arnhof H, Peric-Simov B, Hofbauer KS, Garavel G, Scherbantin Y, Mitzner S, Fett TN, Scholz G, Bruchhaus J, Burkard M, Kousek R, Ciftci T, Sharps B, Schrenk A, Harrer C, Haering D, Wolkerstorfer B, Zhang X, Lv X, Du A, Li D, Li Y, Quant J, Pearson M, McConnell DB.
Weinstabl H, et al. Among authors: garavel g.
J Med Chem. 2019 Sep 12;62(17):7976-7997. doi: 10.1021/acs.jmedchem.9b00718. Epub 2019 Aug 14.
J Med Chem. 2019.
PMID: 31365252
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Single bead labeling method for combining confocal fluorescence on-bead screening and solution validation of tagged one-bead one-compound libraries.
Hintersteiner M, Kimmerlin T, Kalthoff F, Stoeckli M, Garavel G, Seifert JM, Meisner NC, Uhl V, Buehler C, Weidemann T, Auer M.
Hintersteiner M, et al. Among authors: garavel g.
Chem Biol. 2009 Jul 31;16(7):724-35. doi: 10.1016/j.chembiol.2009.06.011.
Chem Biol. 2009.
PMID: 19635409
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A highly potent and cellularly active beta-peptidic inhibitor of the p53/hDM2 interaction.
Hintersteiner M, Kimmerlin T, Garavel G, Schindler T, Bauer R, Meisner NC, Seifert JM, Uhl V, Auer M.
Hintersteiner M, et al. Among authors: garavel g.
Chembiochem. 2009 Apr 17;10(6):994-8. doi: 10.1002/cbic.200800803.
Chembiochem. 2009.
PMID: 19267375
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