Hu W - Search Results

1

Gemtuzumab Ozogamicin Treatment Results in Decreased Proliferation and Differentiation of Human Megakaryocytes but Does Not Inhibit Mature Platelet Function.

Vitsky A, Sacaan A, Hu W, Finkelstein M, Reagan W. Vitsky A, et al. Among authors: hu w. Toxicol Pathol. 2022 Oct;50(7):871-880. doi: 10.1177/01926233221129202. Epub 2022 Oct 6. Toxicol Pathol. 2022. PMID: 36200575

2

Mechanistic Investigation of Bone Marrow Suppression Associated with Palbociclib and its Differentiation from Cytotoxic Chemotherapies.

Hu W, Sung T, Jessen BA, Thibault S, Finkelstein MB, Khan NK, Sacaan AI. Hu W, et al. Clin Cancer Res. 2016 Apr 15;22(8):2000-8. doi: 10.1158/1078-0432.CCR-15-1421. Epub 2015 Dec 2. Clin Cancer Res. 2016. PMID: 26631614

3

Evaluation of miR-216a and miR-217 as Potential Biomarkers of Acute Exocrine Pancreatic Toxicity in Rats.

Wang J, Huang W, Thibault S, Brown TP, Bobrowski W, Gukasyan HJ, Evering W, Hu W, John-Baptiste A, Vitsky A. Wang J, et al. Among authors: hu w. Toxicol Pathol. 2017 Feb;45(2):321-334. doi: 10.1177/0192623316678090. Epub 2016 Dec 26. Toxicol Pathol. 2017. PMID: 28013573

4

Intestinal Toxicity in Rats Following Administration of CDK4/6 Inhibitors Is Independent of Primary Pharmacology.

Thibault S, Hu W, Hirakawa B, Kalabat D, Franks T, Sung T, Khoh-Reiter S, Lu S, Finkelstein M, Jessen B, Sacaan A. Thibault S, et al. Among authors: hu w. Mol Cancer Ther. 2019 Feb;18(2):257-266. doi: 10.1158/1535-7163.MCT-18-0734. Epub 2018 Nov 6. Mol Cancer Ther. 2019. PMID: 30401694

5

Liver Toxicity Observed With Lorlatinib When Combined With Strong CYP3A Inducers: Evaluation of Cynomolgus Monkey as a Nonclinical Model for Assessing the Mechanism of Combinational Toxicity.

Hu W, Lettiere D, Tse S, Johnson TR, Biddle KE, Thibault S, Palazzi X, Chen J, Pithavala YK, Finkelstein M. Hu W, et al. Toxicol Sci. 2021 Aug 3;182(2):183-194. doi: 10.1093/toxsci/kfab056. Toxicol Sci. 2021. PMID: 34021354

6

Comparative Analyses of Poly(ADP-Ribose) Polymerase Inhibitors.

Guha M, Sobol Z, Martin M, Hemkens M, Sung T, Rubitski E, Spellman R, Finkelstein M, Khan N, Hu W. Guha M, et al. Among authors: hu w. Int J Toxicol. 2022 Dec;41(6):442-454. doi: 10.1177/10915818221121325. Epub 2022 Aug 21. Int J Toxicol. 2022. PMID: 35989659

7

Use of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities.

Yenerall P, Sung T, Palyada K, Qian J, Arat S, Kumpf SW, Wang SW, Biddle K, Esparza C, Chang S, Scott W, Collette W, Winrow TS, Affolter T, Shirai N, Thibault S, Wang J, Liu L, Bauchmann M, Frey J, Steyn S, Sacaan A, Vitsky A, Ahn Y, Paul T, Lum L, Oyer J, Yang A, Hu W. Yenerall P, et al. Among authors: hu w. Toxicol Sci. 2023 Jun 28;194(1):53-69. doi: 10.1093/toxsci/kfad049. Toxicol Sci. 2023. PMID: 37228089 Free PMC article.

8

Immune-Mediated Liver Effects Associated With Administration of a Human Anti-IL-21 Receptor Antibody (ATR-107) in Rats.

Hu W, Buetow BS, Sachdeva K, Leach MW. Hu W, et al. Toxicol Pathol. 2024 Jul;52(5):232-250. doi: 10.1177/01926233241259011. Epub 2024 Jul 25. Toxicol Pathol. 2024. PMID: 39049757

9

Development of Highly Optimized Antibody-Drug Conjugates against CD33 and CD123 for Acute Myeloid Leukemia.

Han YC, Kahler J, Piché-Nicholas N, Hu W, Thibault S, Jiang F, Leal M, Katragadda M, Maderna A, Dushin R, Prashad N, Charati MB, Clark T, Tumey LN, Tan X, Giannakou A, Rosfjord E, Gerber HP, Tchistiakova L, Loganzo F, O'Donnell CJ, Sapra P. Han YC, et al. Among authors: hu w. Clin Cancer Res. 2021 Jan 15;27(2):622-631. doi: 10.1158/1078-0432.CCR-20-2149. Epub 2020 Nov 4. Clin Cancer Res. 2021. PMID: 33148666

10

Predicting Chemotherapy-Induced Neutropenia and Granulocyte Colony-Stimulating Factor Response Using Model-Based In Vitro to Clinical Translation.

Chen W, Boras B, Sung T, Hu W, Spilker ME, D'Argenio DZ. Chen W, et al. Among authors: hu w. AAPS J. 2020 Nov 6;22(6):143. doi: 10.1208/s12248-020-00529-x. AAPS J. 2020. PMID: 33156437 Free PMC article. Clinical Trial.

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