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Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function.
Notarangelo G, Spinelli JB, Perez EM, Baker GJ, Kurmi K, Elia I, Stopka SA, Baquer G, Lin JR, Golby AJ, Joshi S, Baron HF, Drijvers JM, Georgiev P, Ringel AE, Zaganjor E, McBrayer SK, Sorger PK, Sharpe AH, Wucherpfennig KW, Santagata S, Agar NYR, Suvà ML, Haigis MC. Notarangelo G, et al. Among authors: georgiev p. Science. 2022 Sep 30;377(6614):1519-1529. doi: 10.1126/science.abj5104. Epub 2022 Sep 29. Science. 2022. PMID: 36173860 Free PMC article.
Age-associated remodeling of T cell immunity and metabolism.
Han S, Georgiev P, Ringel AE, Sharpe AH, Haigis MC. Han S, et al. Among authors: georgiev p. Cell Metab. 2023 Jan 3;35(1):36-55. doi: 10.1016/j.cmet.2022.11.005. Epub 2022 Dec 5. Cell Metab. 2023. PMID: 36473467 Free PMC article. Review.
Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity.
Georgiev P, Han S, Huang AY, Nguyen TH, Drijvers JM, Creasey H, Pereira JA, Yao CH, Park JS, Conway TS, Fung ME, Liang D, Peluso M, Joshi S, Rowe JH, Miller BC, Freeman GJ, Sharpe AH, Haigis MC, Ringel AE. Georgiev P, et al. Cancer Immunol Res. 2024 Nov 4;12(11):1525-1541. doi: 10.1158/2326-6066.CIR-24-0463. Cancer Immunol Res. 2024. PMID: 39186561 Free PMC article.
IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy.
Schmitt EG, Haribhai D, Williams JB, Aggarwal P, Jia S, Charbonnier LM, Yan K, Lorier R, Turner A, Ziegelbauer J, Georgiev P, Simpson P, Salzman NH, Hessner MJ, Broeckel U, Chatila TA, Williams CB. Schmitt EG, et al. Among authors: georgiev p. J Immunol. 2012 Dec 15;189(12):5638-48. doi: 10.4049/jimmunol.1200936. Epub 2012 Nov 2. J Immunol. 2012. PMID: 23125413 Free PMC article.
Regulatory T Cells: the Many Faces of Foxp3.
Georgiev P, Charbonnier LM, Chatila TA. Georgiev P, et al. J Clin Immunol. 2019 Oct;39(7):623-640. doi: 10.1007/s10875-019-00684-7. Epub 2019 Sep 2. J Clin Immunol. 2019. PMID: 31478130 Free PMC article. Review.
Cancer-Associated Fibroblasts Promote Immunosuppression by Inducing ROS-Generating Monocytic MDSCs in Lung Squamous Cell Carcinoma.
Xiang H, Ramil CP, Hai J, Zhang C, Wang H, Watkins AA, Afshar R, Georgiev P, Sze MA, Song XS, Curran PJ, Cheng M, Miller JR, Sun D, Loboda A, Jia Y, Moy LY, Chi A, Brandish PE. Xiang H, et al. Among authors: georgiev p. Cancer Immunol Res. 2020 Apr;8(4):436-450. doi: 10.1158/2326-6066.CIR-19-0507. Epub 2020 Feb 19. Cancer Immunol Res. 2020. PMID: 32075803
478 results