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High certainty evidence is stable and trustworthy, whereas evidence of moderate or lower certainty may be equally prone to being unstable.
Djulbegovic B, Koletsi D, Hozo I, Price A, Martimbianco ALC, Riera R, Nadanovsky P, Dos Santos APP, Pandis N, Pacheco RL, Fontes LE, Seehra J, Ahmed M, Yao L, Nunan D, Hemkens LG. Djulbegovic B, et al. Among authors: dos santos app. J Clin Epidemiol. 2024 Jul;171:111392. doi: 10.1016/j.jclinepi.2024.111392. Epub 2024 May 11. J Clin Epidemiol. 2024. PMID: 38740313 Free article.
High quality (certainty) evidence changes less often than low-quality evidence, but the magnitude of effect size does not systematically differ between studies with low versus high-quality evidence.
Djulbegovic B, Ahmed MM, Hozo I, Koletsi D, Hemkens L, Price A, Riera R, Nadanovsky P, Dos Santos APP, Melo D, Pathak R, Pacheco RL, Fontes LE, Miranda E, Nunan D. Djulbegovic B, et al. Among authors: dos santos app. J Eval Clin Pract. 2022 Jun;28(3):353-362. doi: 10.1111/jep.13657. Epub 2022 Jan 28. J Eval Clin Pract. 2022. PMID: 35089627 Free PMC article.
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