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Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays.
Pharmaceuticals (Basel). 2023 Sep 18;16(9):1316. doi: 10.3390/ph16091316.
Pharmaceuticals (Basel). 2023.
PMID: 37765125
Free PMC article.
SIRT6 pharmacological inhibition delays skin cancer progression in the squamous cell carcinoma.
Abbotto E, Miro C, Piacente F, Salis A, Murolo M, Nappi A, Millo E, Russo E, Cichero E, Sturla L, Del Rio A, De Flora A, Nencioni A, Dentice M, Bruzzone S.
Abbotto E, et al.
Biomed Pharmacother. 2023 Oct;166:115326. doi: 10.1016/j.biopha.2023.115326. Epub 2023 Aug 21.
Biomed Pharmacother. 2023.
PMID: 37611438
Free article.
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Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors.
Scarano N, Abbotto E, Musumeci F, Salis A, Brullo C, Fossa P, Schenone S, Bruzzone S, Cichero E.
Scarano N, et al. Among authors: abbotto e.
Int J Mol Sci. 2023 May 27;24(11):9363. doi: 10.3390/ijms24119363.
Int J Mol Sci. 2023.
PMID: 37298312
Free PMC article.
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Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage.
Nappi A, Miro C, Pezone A, Tramontano A, Di Cicco E, Sagliocchi S, Cicatiello AG, Murolo M, Torabinejad S, Abbotto E, Caiazzo G, Raia M, Stornaiuolo M, Antonini D, Fabbrocini G, Salvatore D, Avvedimento VE, Dentice M.
Nappi A, et al. Among authors: abbotto e.
Nat Commun. 2023 Mar 4;14(1):1244. doi: 10.1038/s41467-023-36755-y.
Nat Commun. 2023.
PMID: 36871014
Free PMC article.
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Sirtuin 6 inhibition protects against glucocorticoid-induced skeletal muscle atrophy by regulating IGF/PI3K/AKT signaling.
Mishra S, Cosentino C, Tamta AK, Khan D, Srinivasan S, Ravi V, Abbotto E, Arathi BP, Kumar S, Jain A, Ramaian AS, Kizkekra SM, Rajagopal R, Rao S, Krishna S, Asirvatham-Jeyaraj N, Haggerty ER, Silberman DM, Kurland IJ, Veeranna RP, Jayavelu T, Bruzzone S, Mostoslavsky R, Sundaresan NR.
Mishra S, et al. Among authors: abbotto e.
Nat Commun. 2022 Sep 15;13(1):5415. doi: 10.1038/s41467-022-32905-w.
Nat Commun. 2022.
PMID: 36109503
Free PMC article.
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Virtual Screening in the Identification of Sirtuins' Activity Modulators.
Abbotto E, Scarano N, Piacente F, Millo E, Cichero E, Bruzzone S.
Abbotto E, et al.
Molecules. 2022 Sep 1;27(17):5641. doi: 10.3390/molecules27175641.
Molecules. 2022.
PMID: 36080416
Free PMC article.
Review.
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Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration.
Ferrara G, Benzi A, Sturla L, Marubbi D, Frumento D, Spinelli S, Abbotto E, Ivaldi F, von Holtey M, Murone M, Nencioni A, Uccelli A, Bruzzone S.
Ferrara G, et al. Among authors: abbotto e.
J Neuroinflammation. 2020 Jul 31;17(1):228. doi: 10.1186/s12974-020-01906-1.
J Neuroinflammation. 2020.
PMID: 32736564
Free PMC article.
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