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Page 1
Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1.
Prattes M, Grishkovskaya I, Hodirnau VV, Hetzmannseder C, Zisser G, Sailer C, Kargas V, Loibl M, Gerhalter M, Kofler L, Warren AJ, Stengel F, Haselbach D, Bergler H. Prattes M, et al. Among authors: grishkovskaya i. Nat Struct Mol Biol. 2022 Sep;29(9):942-953. doi: 10.1038/s41594-022-00832-5. Epub 2022 Sep 12. Nat Struct Mol Biol. 2022. PMID: 36097293 Free PMC article.
Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine.
Prattes M, Grishkovskaya I, Hodirnau VV, Rössler I, Klein I, Hetzmannseder C, Zisser G, Gruber CC, Gruber K, Haselbach D, Bergler H. Prattes M, et al. Among authors: grishkovskaya i. Nat Commun. 2021 Jun 9;12(1):3483. doi: 10.1038/s41467-021-23854-x. Nat Commun. 2021. PMID: 34108481 Free PMC article.
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.
Grabarczyk DB, Petrova OA, Deszcz L, Kurzbauer R, Murphy P, Ahel J, Vogel A, Gogova R, Faas V, Kordic D, Schleiffer A, Meinhart A, Imre R, Lehner A, Neuhold J, Bader G, Stolt-Bergner P, Böttcher J, Wolkerstorfer B, Fischer G, Grishkovskaya I, Haselbach D, Kessler D, Clausen T. Grabarczyk DB, et al. Among authors: grishkovskaya i. Nat Chem Biol. 2021 Oct;17(10):1084-1092. doi: 10.1038/s41589-021-00831-5. Epub 2021 Jul 22. Nat Chem Biol. 2021. PMID: 34294896 Free PMC article.
Structure of the peripheral arm of a minimalistic respiratory complex I.
Schimpf J, Oppermann S, Gerasimova T, Santos Seica AF, Hellwig P, Grishkovskaya I, Wohlwend D, Haselbach D, Friedrich T. Schimpf J, et al. Among authors: grishkovskaya i. Structure. 2022 Jan 6;30(1):80-94.e4. doi: 10.1016/j.str.2021.09.005. Epub 2021 Sep 24. Structure. 2022. PMID: 34562374 Free article.
AKIRIN2 controls the nuclear import of proteasomes in vertebrates.
de Almeida M, Hinterndorfer M, Brunner H, Grishkovskaya I, Singh K, Schleiffer A, Jude J, Deswal S, Kalis R, Vunjak M, Lendl T, Imre R, Roitinger E, Neumann T, Kandolf S, Schutzbier M, Mechtler K, Versteeg GA, Haselbach D, Zuber J. de Almeida M, et al. Among authors: grishkovskaya i. Nature. 2021 Nov;599(7885):491-496. doi: 10.1038/s41586-021-04035-8. Epub 2021 Oct 28. Nature. 2021. PMID: 34711951
Cryo-EM structure of the plant 26S proteasome.
Kandolf S, Grishkovskaya I, Belačić K, Bolhuis DL, Amann S, Foster B, Imre R, Mechtler K, Schleiffer A, Tagare HD, Zhong ED, Meinhart A, Brown NG, Haselbach D. Kandolf S, et al. Among authors: grishkovskaya i. Plant Commun. 2022 May 9;3(3):100310. doi: 10.1016/j.xplc.2022.100310. Epub 2022 Mar 11. Plant Commun. 2022. PMID: 35576154 Free PMC article.
A molecular network of conserved factors keeps ribosomes dormant in the egg.
Leesch F, Lorenzo-Orts L, Pribitzer C, Grishkovskaya I, Roehsner J, Chugunova A, Matzinger M, Roitinger E, Belačić K, Kandolf S, Lin TY, Mechtler K, Meinhart A, Haselbach D, Pauli A. Leesch F, et al. Among authors: grishkovskaya i. Nature. 2023 Jan;613(7945):712-720. doi: 10.1038/s41586-022-05623-y. Epub 2023 Jan 18. Nature. 2023. PMID: 36653451 Free PMC article.
Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5.
Hodáková Z, Grishkovskaya I, Brunner HL, Bolhuis DL, Belačić K, Schleiffer A, Kotisch H, Brown NG, Haselbach D. Hodáková Z, et al. Among authors: grishkovskaya i. EMBO J. 2023 Aug 15;42(16):e113348. doi: 10.15252/embj.2022113348. Epub 2023 Jul 6. EMBO J. 2023. PMID: 37409633 Free PMC article.
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Bodrug T, Welsh KA, Bolhuis DL, Paulаkonis E, Martinez-Chacin RC, Liu B, Pinkin N, Bonacci T, Cui L, Xu P, Roscow O, Amann SJ, Grishkovskaya I, Emanuele MJ, Harrison JS, Steimel JP, Hahn KM, Zhang W, Zhong ED, Haselbach D, Brown NG. Bodrug T, et al. Among authors: grishkovskaya i. Nat Struct Mol Biol. 2023 Nov;30(11):1663-1674. doi: 10.1038/s41594-023-01105-5. Epub 2023 Sep 21. Nat Struct Mol Biol. 2023. PMID: 37735619 Free PMC article.
The novel ribosome biogenesis inhibitor usnic acid blocks nucleolar pre-60S maturation.
Kofler L, Grundmann L, Gerhalter M, Prattes M, Merl-Pham J, Zisser G, Grishkovskaya I, Hodirnau VV, Vareka M, Breinbauer R, Hauck SM, Haselbach D, Bergler H. Kofler L, et al. Among authors: grishkovskaya i. Nat Commun. 2024 Aug 29;15(1):7511. doi: 10.1038/s41467-024-51754-3. Nat Commun. 2024. PMID: 39209816 Free PMC article.
35 results