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Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration.
Fialova JL, Hönigova K, Raudenska M, Miksatkova L, Zobalova R, Navratil J, Šmigová J, Moturu TR, Vicar T, Balvan J, Vesela K, Abramenko N, Kejik Z, Kaplanek R, Gumulec J, Rosel D, Martasek P, Brábek J, Jakubek M, Neuzil J, Masarik M. Fialova JL, et al. Among authors: neuzil j. Biomed Pharmacother. 2022 Oct;154:113582. doi: 10.1016/j.biopha.2022.113582. Epub 2022 Aug 30. Biomed Pharmacother. 2022. PMID: 36055111 Free article.
CD133-positive cells are resistant to TRAIL due to up-regulation of FLIP.
Zobalova R, McDermott L, Stantic M, Prokopova K, Dong LF, Neuzil J. Zobalova R, et al. Among authors: neuzil j. Biochem Biophys Res Commun. 2008 Sep 5;373(4):567-71. doi: 10.1016/j.bbrc.2008.06.073. Epub 2008 Jun 30. Biochem Biophys Res Commun. 2008. PMID: 18590703
Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: a new paradigm for effective cancer therapy.
Dong LF, Jameson VJ, Tilly D, Prochazka L, Rohlena J, Valis K, Truksa J, Zobalova R, Mahdavian E, Kluckova K, Stantic M, Stursa J, Freeman R, Witting PK, Norberg E, Goodwin J, Salvatore BA, Novotna J, Turanek J, Ledvina M, Hozak P, Zhivotovsky B, Coster MJ, Ralph SJ, Smith RA, Neuzil J. Dong LF, et al. Among authors: neuzil j. Free Radic Biol Med. 2011 Jun 1;50(11):1546-55. doi: 10.1016/j.freeradbiomed.2011.02.032. Epub 2011 Mar 12. Free Radic Biol Med. 2011. PMID: 21402148
246 results