Hou K - Search Results

1

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data.

Zhang MJ, Hou K, Dey KK, Sakaue S, Jagadeesh KA, Weinand K, Taychameekiatchai A, Rao P, Pisco AO, Zou J, Wang B, Gandal M, Raychaudhuri S, Pasaniuc B, Price AL. Zhang MJ, et al. Among authors: hou k. Nat Genet. 2022 Oct;54(10):1572-1580. doi: 10.1038/s41588-022-01167-z. Epub 2022 Sep 1. Nat Genet. 2022. PMID: 36050550 Free PMC article.

2

Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture.

Hou K, Burch KS, Majumdar A, Shi H, Mancuso N, Wu Y, Sankararaman S, Pasaniuc B. Hou K, et al. Nat Genet. 2019 Aug;51(8):1244-1251. doi: 10.1038/s41588-019-0465-0. Epub 2019 Jul 29. Nat Genet. 2019. PMID: 31358995 Free PMC article.

3

Efficient variance components analysis across millions of genomes.

Pazokitoroudi A, Wu Y, Burch KS, Hou K, Zhou A, Pasaniuc B, Sankararaman S. Pazokitoroudi A, et al. Among authors: hou k. Nat Commun. 2020 Aug 11;11(1):4020. doi: 10.1038/s41467-020-17576-9. Nat Commun. 2020. PMID: 32782262 Free PMC article.

4

Optimized design of single-cell RNA sequencing experiments for cell-type-specific eQTL analysis.

Mandric I, Schwarz T, Majumdar A, Hou K, Briscoe L, Perez R, Subramaniam M, Hafemeister C, Satija R, Ye CJ, Pasaniuc B, Halperin E. Mandric I, et al. Among authors: hou k. Nat Commun. 2020 Oct 30;11(1):5504. doi: 10.1038/s41467-020-19365-w. Nat Commun. 2020. PMID: 33127880 Free PMC article.

5

Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization.

Pathak GA, Singh K, Miller-Fleming TW, Wendt FR, Ehsan N, Hou K, Johnson R, Lu Z, Gopalan S, Yengo L, Mohammadi P, Pasaniuc B, Polimanti R, Davis LK, Mancuso N. Pathak GA, et al. Among authors: hou k. Nat Commun. 2021 Jul 27;12(1):4569. doi: 10.1038/s41467-021-24824-z. Nat Commun. 2021. PMID: 34315903 Free PMC article.

6

Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits.

Johnson R, Burch KS, Hou K, Paciuc M, Pasaniuc B, Sankararaman S. Johnson R, et al. Among authors: hou k. PLoS Comput Biol. 2021 Oct 21;17(10):e1009483. doi: 10.1371/journal.pcbi.1009483. eCollection 2021 Oct. PLoS Comput Biol. 2021. PMID: 34673766 Free PMC article.

7

On powerful GWAS in admixed populations.

Hou K, Bhattacharya A, Mester R, Burch KS, Pasaniuc B. Hou K, et al. Nat Genet. 2021 Dec;53(12):1631-1633. doi: 10.1038/s41588-021-00953-5. Epub 2021 Nov 25. Nat Genet. 2021. PMID: 34824480 Free PMC article. No abstract available.

8

Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification.

Ding Y, Hou K, Burch KS, Lapinska S, Privé F, Vilhjálmsson B, Sankararaman S, Pasaniuc B. Ding Y, et al. Among authors: hou k. Nat Genet. 2022 Jan;54(1):30-39. doi: 10.1038/s41588-021-00961-5. Epub 2021 Dec 20. Nat Genet. 2022. PMID: 34931067 Free PMC article.

9

A multi-dimensional integrative scoring framework for predicting functional variants in the human genome.

Li X, Yung G, Zhou H, Sun R, Li Z, Hou K, Zhang MJ, Liu Y, Arapoglou T, Wang C, Ionita-Laza I, Lin X. Li X, et al. Among authors: hou k. Am J Hum Genet. 2022 Mar 3;109(3):446-456. doi: 10.1016/j.ajhg.2022.01.017. Epub 2022 Feb 24. Am J Hum Genet. 2022. PMID: 35216679 Free PMC article.

10

Partitioning gene-level contributions to complex-trait heritability by allele frequency identifies disease-relevant genes.

Burch KS, Hou K, Ding Y, Wang Y, Gazal S, Shi H, Pasaniuc B. Burch KS, et al. Among authors: hou k. Am J Hum Genet. 2022 Apr 7;109(4):692-709. doi: 10.1016/j.ajhg.2022.02.012. Epub 2022 Mar 9. Am J Hum Genet. 2022. PMID: 35271803 Free PMC article.

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