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Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer.
Cronin SJF, Rao S, Tejada MA, Turnes BL, Licht-Mayer S, Omura T, Brenneis C, Jacobs E, Barrett L, Latremoliere A, Andrews N, Channon KM, Latini A, Arvanites AC, Davidow LS, Costigan M, Rubin LL, Penninger JM, Woolf CJ. Cronin SJF, et al. Among authors: latremoliere a. Sci Transl Med. 2022 Aug 31;14(660):eabj1531. doi: 10.1126/scitranslmed.abj1531. Epub 2022 Aug 31. Sci Transl Med. 2022. PMID: 36044597 Free PMC article.
GCH1, BH4 and pain.
Latremoliere A, Costigan M. Latremoliere A, et al. Curr Pharm Biotechnol. 2011 Oct;12(10):1728-41. doi: 10.2174/138920111798357393. Curr Pharm Biotechnol. 2011. PMID: 21466440 Free PMC article. Review.
Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice.
Ma CH, Omura T, Cobos EJ, Latrémolière A, Ghasemlou N, Brenner GJ, van Veen E, Barrett L, Sawada T, Gao F, Coppola G, Gertler F, Costigan M, Geschwind D, Woolf CJ. Ma CH, et al. Among authors: latremoliere a. J Clin Invest. 2011 Nov;121(11):4332-47. doi: 10.1172/JCI58675. Epub 2011 Oct 3. J Clin Invest. 2011. PMID: 21965333 Free PMC article.
Analgesia by inhibiting tetrahydrobiopterin synthesis.
Costigan M, Latremoliere A, Woolf CJ. Costigan M, et al. Among authors: latremoliere a. Curr Opin Pharmacol. 2012 Feb;12(1):92-9. doi: 10.1016/j.coph.2011.10.019. Epub 2011 Dec 15. Curr Opin Pharmacol. 2012. PMID: 22178186 Free PMC article. Review.
The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.
Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R. Vicuña L, et al. Among authors: latremoliere a. Nat Med. 2015 May;21(5):518-23. doi: 10.1038/nm.3852. Epub 2015 Apr 27. Nat Med. 2015. PMID: 25915831 Free PMC article.
53 results