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The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture.
Bullen HE, Sanders PR, Dans MG, Jonsdottir TK, Riglar DT, Looker O, Palmer CS, Kouskousis B, Charnaud SC, Triglia T, Gabriela M, Parkyn Schneider M, Chan JA, de Koning-Ward TF, Baum J, Kazura JW, Beeson JG, Cowman AF, Gilson PR, Crabb BS. Bullen HE, et al. Among authors: looker o. Mol Microbiol. 2022 May;117(5):1245-1262. doi: 10.1111/mmi.14904. Epub 2022 Apr 25. Mol Microbiol. 2022. PMID: 35403274 Free PMC article.
The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts.
Parkyn Schneider M, Looker O, Rebelo M, Khoury DS, Dixon MWA, Oeuvray C, Crabb BS, McCarthy J, Gilson PR. Parkyn Schneider M, et al. Among authors: looker o. Front Cell Infect Microbiol. 2023 Jun 29;13:1211613. doi: 10.3389/fcimb.2023.1211613. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37457953 Free PMC article.
A Pyridyl-Furan Series Developed from the Open Global Health Library Block Red Blood Cell Invasion and Protein Trafficking in Plasmodium falciparum through Potential Inhibition of the Parasite's PI4KIIIB Enzyme.
Ling DB, Nguyen W, Looker O, Razook Z, McCann K, Barry AE, Scheurer C, Wittlin S, Famodimu MT, Delves MJ, Bullen HE, Crabb BS, Sleebs BE, Gilson PR. Ling DB, et al. Among authors: looker o. ACS Infect Dis. 2023 Sep 8;9(9):1695-1710. doi: 10.1021/acsinfecdis.3c00138. Epub 2023 Aug 28. ACS Infect Dis. 2023. PMID: 37639221 Free PMC article.
The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites.
Weiss GE, Ragotte RJ, Quinkert D, Lias AM, Dans MG, Boulet C, Looker O, Ventura OD, Williams BG, Crabb BS, Draper SJ, Gilson PR. Weiss GE, et al. Among authors: looker o. PLoS Pathog. 2023 Sep 15;19(9):e1011182. doi: 10.1371/journal.ppat.1011182. eCollection 2023 Sep. PLoS Pathog. 2023. PMID: 37713419 Free PMC article.
Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages.
Dearnley M, Chu T, Zhang Y, Looker O, Huang C, Klonis N, Yeoman J, Kenny S, Arora M, Osborne JM, Chandramohanadas R, Zhang S, Dixon MW, Tilley L. Dearnley M, et al. Among authors: looker o. Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4800-5. doi: 10.1073/pnas.1520194113. Epub 2016 Apr 11. Proc Natl Acad Sci U S A. 2016. PMID: 27071094 Free PMC article.
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