Shah D - Search Results

1

Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3.

Liu C, Jalagam PR, Feng J, Wang W, Raja T, Sura MR, Manepalli RKVLP, Aliphedi BR, Medavarapu S, Nair SK, Muthalagu V, Natesan R, Gupta A, Beno B, Panda M, Ghosh K, Shukla JK, Sale H, Haldar P, Kalidindi N, Shah D, Patel D, Mathur A, Ellsworth BA, Cheng D, Regueiro-Ren A. Liu C, et al. Among authors: shah d. J Med Chem. 2022 Aug 25;65(16):11084-11099. doi: 10.1021/acs.jmedchem.2c00517. Epub 2022 Aug 15. J Med Chem. 2022. PMID: 35969688

2

Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors.

Xu L, Hartz RA, Beno BR, Ghosh K, Shukla JK, Kumar A, Patel D, Kalidindi N, Lemos N, Gautam SS, Kumar A, Ellsworth BA, Shah D, Sale H, Cheng D, Regueiro-Ren A. Xu L, et al. Among authors: shah d. J Med Chem. 2021 May 27;64(10):6634-6655. doi: 10.1021/acs.jmedchem.0c02001. Epub 2021 May 14. J Med Chem. 2021. PMID: 33988358

3

Exploring monocyclic core: Discovery of pyrrol-2-one derivatives as a new series of potent MCHR1 antagonists with in vivo efficacy.

A M Subbaiah M, Mandal U, Patankar V, Bhaskaran S, Nutakki R, Rami B, Shah DP, Mahammad S, Murphy BJ, Huang C, Robl JA, Washburn WN. A M Subbaiah M, et al. Eur J Med Chem. 2024 Oct 5;276:116686. doi: 10.1016/j.ejmech.2024.116686. Epub 2024 Jul 20. Eur J Med Chem. 2024. PMID: 39053192

4

Evaluation of Encequidar as An Intestinal P-gp and BCRP Specific Inhibitor to Assess the Role of Intestinal P-gp and BCRP in Drug-Drug Interactions.

Chu J, Panfen E, Wang L, Marino A, Chen XQ, Fancher RM, Landage R, Patil O, Desai SD, Shah D, Xue Y, Sinz M, Shen H. Chu J, et al. Among authors: shah d. Pharm Res. 2023 Nov;40(11):2567-2584. doi: 10.1007/s11095-023-03563-4. Epub 2023 Jul 31. Pharm Res. 2023. PMID: 37523014

5

Prediction of pH dependent absorption using in vitro, in silico, and in vivo rat models: Early liability assessment during lead optimization.

Saxena A, Shah D, Padmanabhan S, Gautam SS, Chowan GS, Mandlekar S, Desikan S. Saxena A, et al. Among authors: shah d. Eur J Pharm Sci. 2015 Aug 30;76:173-80. doi: 10.1016/j.ejps.2015.05.006. Epub 2015 May 8. Eur J Pharm Sci. 2015. PMID: 25960252

6

Absolute quantification of imipramine and its metabolites in vivo utilizing calibrators from radiolabeled in vitro incubations.

Bhutani P, Shah D, Varkhede N, Mandlekar S, Chacko S, Subramanian M. Bhutani P, et al. Among authors: shah d. Bioanalysis. 2016 Feb;8(4):297-309. doi: 10.4155/bio.15.259. Epub 2016 Feb 5. Bioanalysis. 2016. PMID: 26847656

7

A systematic evaluation of solubility enhancing excipients to enable the generation of permeability data for poorly soluble compounds in Caco-2 model.

Shah D, Paruchury S, Matta M, Chowan G, Subramanian M, Saxena A, Soars MG, Herbst J, Haskell R, Marathe P, Mandlekar S. Shah D, et al. Drug Metab Lett. 2014;8(2):109-18. doi: 10.2174/1872312808666141127113055. Drug Metab Lett. 2014. PMID: 25429513

8

Implementing the Global Action Plan on Biodiversity and Health.

Willetts L, van de Pas R, Woolaston K, Bennett NJ, Vora NM, Shah D, Atkinson AR, Stewart-Ibarra A. Willetts L, et al. Among authors: shah d. Lancet. 2024 Nov 27:S0140-6736(24)02557-1. doi: 10.1016/S0140-6736(24)02557-1. Online ahead of print. Lancet. 2024. PMID: 39615507 No abstract available.

9

Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4-b]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis.

Foutz MA, Krinos EL, Beretta M, Hargett SR, Shrestha R, Murray JH, Duerre E, Salamoun JM, McCarter K, Shah DP, Hoehn KL, Santos WL. Foutz MA, et al. Among authors: shah dp. J Med Chem. 2024 Nov 30. doi: 10.1021/acs.jmedchem.4c02366. Online ahead of print. J Med Chem. 2024. PMID: 39614818

10

EP4: A prostanoid receptor that modulates insulin signalling in rat skeletal muscle cells.

Nisr RB, Shah DS, Hundal HS. Nisr RB, et al. Among authors: shah ds. Cell Signal. 2024 Nov 24;126:111516. doi: 10.1016/j.cellsig.2024.111516. Online ahead of print. Cell Signal. 2024. PMID: 39592018 Review.

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