Xia G - Search Results

1

Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor.

Iijima D, Sugama H, Takahashi Y, Hirai M, Togashi Y, Xie J, Shen J, Ke Y, Akatsuka H, Kawaguchi T, Takedomi K, Kashima A, Nishio M, Inui Y, Yoneda H, Xia G, Iijima T. Iijima D, et al. Among authors: xia g. J Med Chem. 2022 Aug 25;65(16):10882-10897. doi: 10.1021/acs.jmedchem.2c00834. Epub 2022 Aug 8. J Med Chem. 2022. PMID: 35939295

2

Potent and novel 11β-HSD1 inhibitors identified from shape and docking based virtual screening.

Xia G, Xue M, Liu L, Yu J, Liu H, Li P, Wang J, Li Y, Xiong B, Shen J. Xia G, et al. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5739-44. doi: 10.1016/j.bmcl.2011.08.019. Epub 2011 Aug 8. Bioorg Med Chem Lett. 2011. PMID: 21873057

3

Discovery of novel sulfonamides as potent and selective inhibitors against human and mouse 11β-hydroxysteroid dehydrogenase type 1.

Xia G, Liu L, Xue M, Liu H, Yu J, Li P, Chen Q, Xiong B, Liu X, Shen J. Xia G, et al. Mol Cell Endocrinol. 2012 Jul 6;358(1):46-52. doi: 10.1016/j.mce.2012.02.017. Epub 2012 Mar 3. Mol Cell Endocrinol. 2012. PMID: 22410288

4

Design, synthesis and SAR of piperidyl-oxadiazoles as 11β-hydroxysteroid dehydrogenase 1 inhibitors.

Xia G, You X, Liu L, Liu H, Wang J, Shi Y, Li P, Xiong B, Liu X, Shen J. Xia G, et al. Eur J Med Chem. 2013 Apr;62:1-10. doi: 10.1016/j.ejmech.2012.12.059. Epub 2013 Jan 10. Eur J Med Chem. 2013. PMID: 23353742

5

Design and synthesis of (R)-1-arylsulfonylpiperidine-2-carboxamides as 11β-hydroxysteroid dehydrogenase type 1 inhibitors.

Xia G, Liu L, Liu H, Yu J, Xu Z, Chen Q, Ma C, Li P, Xiong B, Liu X, Shen J. Xia G, et al. ChemMedChem. 2013 Apr;8(4):577-81. doi: 10.1002/cmdc.201300022. Epub 2013 Mar 7. ChemMedChem. 2013. PMID: 23471829

6

Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors.

Yu J, Liu H, Xia G, Liu L, Xu Z, Chen Q, Ma C, Sun X, Xu J, Li H, Li P, Shi Y, Xiong B, Liu X, Shen J. Yu J, et al. Among authors: xia g. ACS Med Chem Lett. 2012 Sep 20;3(10):793-8. doi: 10.1021/ml300144n. eCollection 2012 Oct 11. ACS Med Chem Lett. 2012. PMID: 24900382 Free PMC article.

7

Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting EGFR.

Wu J, Chen W, Xia G, Zhang J, Shao J, Tan B, Zhang C, Yu W, Weng Q, Liu H, Hu M, Deng H, Hao Y, Shen J, Yu Y. Wu J, et al. Among authors: xia g. ACS Med Chem Lett. 2013 Aug 6;4(10):974-8. doi: 10.1021/ml4002437. eCollection 2013 Oct 10. ACS Med Chem Lett. 2013. PMID: 24900594 Free PMC article.

8

A chemical tuned strategy to develop novel irreversible EGFR-TK inhibitors with improved safety and pharmacokinetic profiles.

Xia G, Chen W, Zhang J, Shao J, Zhang Y, Huang W, Zhang L, Qi W, Sun X, Li B, Xiang Z, Ma C, Xu J, Deng H, Li Y, Li P, Miao H, Han J, Liu Y, Shen J, Yu Y. Xia G, et al. J Med Chem. 2014 Dec 11;57(23):9889-900. doi: 10.1021/jm5014659. Epub 2014 Dec 1. J Med Chem. 2014. PMID: 25409491

9

Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization.

Zhao L, Wang Y, Cao D, Chen T, Wang Q, Li Y, Xu Y, Zhang N, Wang X, Chen D, Chen L, Chen YL, Xia G, Shi Z, Liu YC, Lin Y, Miao Z, Shen J, Xiong B. Zhao L, et al. Among authors: xia g. J Med Chem. 2015 Feb 12;58(3):1281-97. doi: 10.1021/jm501504k. Epub 2015 Jan 14. J Med Chem. 2015. PMID: 25559428

10

Discovery and optimization of a series of imidazo[4,5-b]pyrazine derivatives as highly potent and exquisitely selective inhibitors of the mesenchymal-epithelial transition factor (c-Met) protein kinase.

Zhao F, Zhang J, Zhang L, Hao Y, Shi C, Xia G, Yu J, Liu Y. Zhao F, et al. Among authors: xia g. Bioorg Med Chem. 2016 Sep 15;24(18):4281-4290. doi: 10.1016/j.bmc.2016.07.019. Epub 2016 Jul 12. Bioorg Med Chem. 2016. PMID: 27448775

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