Gupta N - Search Results

1

Phase 1 study to evaluate the effects of rifampin on pharmacokinetics of pevonedistat, a NEDD8-activating enzyme inhibitor in patients with advanced solid tumors.

Zhou X, Vaishampayan U, Mahalingam D, Harvey RD, Chung KY, Sedarati F, Dong C, Faller DV, Venkatakrishnan K, Gupta N. Zhou X, et al. Among authors: gupta n. Invest New Drugs. 2022 Oct;40(5):1042-1050. doi: 10.1007/s10637-022-01286-8. Epub 2022 Aug 6. Invest New Drugs. 2022. PMID: 35932388 Free PMC article. Clinical Trial.

2

Phase 1 study of twice-weekly ixazomib, an oral proteasome inhibitor, in relapsed/refractory multiple myeloma patients.

Richardson PG, Baz R, Wang M, Jakubowiak AJ, Laubach JP, Harvey RD, Talpaz M, Berg D, Liu G, Yu J, Gupta N, Di Bacco A, Hui AM, Lonial S. Richardson PG, et al. Among authors: gupta n. Blood. 2014 Aug 14;124(7):1038-46. doi: 10.1182/blood-2014-01-548826. Epub 2014 Jun 11. Blood. 2014. PMID: 24920586 Free PMC article. Clinical Trial.

3

Switching from body surface area-based to fixed dosing for the investigational proteasome inhibitor ixazomib: a population pharmacokinetic analysis.

Gupta N, Zhao Y, Hui AM, Esseltine DL, Venkatakrishnan K. Gupta N, et al. Br J Clin Pharmacol. 2015 May;79(5):789-800. doi: 10.1111/bcp.12542. Br J Clin Pharmacol. 2015. PMID: 25377318 Free PMC article.

4

Phase 1 study of ixazomib, an investigational proteasome inhibitor, in advanced non-hematologic malignancies.

Smith DC, Kalebic T, Infante JR, Siu LL, Sullivan D, Vlahovic G, Kauh JS, Gao F, Berger AJ, Tirrell S, Gupta N, Di Bacco A, Berg D, Liu G, Lin J, Hui AM, Thompson JA. Smith DC, et al. Among authors: gupta n. Invest New Drugs. 2015 Jun;33(3):652-63. doi: 10.1007/s10637-015-0230-x. Epub 2015 Mar 18. Invest New Drugs. 2015. PMID: 25777468 Free PMC article. Clinical Trial.

5

Integrated nonclinical and clinical risk assessment of the investigational proteasome inhibitor ixazomib on the QTc interval in cancer patients.

Gupta N, Huh Y, Hutmacher MM, Ottinger S, Hui AM, Venkatakrishnan K. Gupta N, et al. Cancer Chemother Pharmacol. 2015 Sep;76(3):507-16. doi: 10.1007/s00280-015-2815-7. Epub 2015 Jul 4. Cancer Chemother Pharmacol. 2015. PMID: 26141494

6

Pharmacokinetics and safety of ixazomib plus lenalidomide-dexamethasone in Asian patients with relapsed/refractory myeloma: a phase 1 study.

Gupta N, Goh YT, Min CK, Lee JH, Kim K, Wong RS, Chim CS, Hanley MJ, Yang H, Venkatakrishnan K, Hui AM, Esseltine DL, Chng WJ. Gupta N, et al. J Hematol Oncol. 2015 Sep 4;8:103. doi: 10.1186/s13045-015-0198-1. J Hematol Oncol. 2015. PMID: 26337806 Free PMC article. Clinical Trial.

7

Toward Optimum Benefit-Risk and Reduced Access Lag For Cancer Drugs in Asia: A Global Development Framework Guided by Clinical Pharmacology Principles.

Venkatakrishnan K, Burgess C, Gupta N, Suri A, Takubo T, Zhou X, DeMuria D, Lehnert M, Takeyama K, Singhvi S, Milton A. Venkatakrishnan K, et al. Among authors: gupta n. Clin Transl Sci. 2016 Feb;9(1):9-22. doi: 10.1111/cts.12386. Epub 2016 Feb 5. Clin Transl Sci. 2016. PMID: 26836226 Free PMC article. Review. No abstract available.

8

The Effect of a High-Fat Meal on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor, in Patients With Advanced Solid Tumors or Lymphoma.

Gupta N, Hanley MJ, Venkatakrishnan K, Wang B, Sharma S, Bessudo A, Hui AM, Nemunaitis J. Gupta N, et al. J Clin Pharmacol. 2016 Oct;56(10):1288-95. doi: 10.1002/jcph.719. Epub 2016 Mar 17. J Clin Pharmacol. 2016. PMID: 26872892 Free PMC article. Clinical Trial.

9

Exposure-safety-efficacy analysis of single-agent ixazomib, an oral proteasome inhibitor, in relapsed/refractory multiple myeloma: dose selection for a phase 3 maintenance study.

Gupta N, Labotka R, Liu G, Hui AM, Venkatakrishnan K. Gupta N, et al. Invest New Drugs. 2016 Jun;34(3):338-46. doi: 10.1007/s10637-016-0346-7. Epub 2016 Apr 2. Invest New Drugs. 2016. PMID: 27039387 Free PMC article. Clinical Trial.

10

Pharmacokinetics of ixazomib, an oral proteasome inhibitor, in solid tumour patients with moderate or severe hepatic impairment.

Gupta N, Hanley MJ, Venkatakrishnan K, Perez R, Norris RE, Nemunaitis J, Yang H, Qian MG, Falchook G, Labotka R, Fu S. Gupta N, et al. Br J Clin Pharmacol. 2016 Sep;82(3):728-38. doi: 10.1111/bcp.12991. Epub 2016 May 29. Br J Clin Pharmacol. 2016. PMID: 27121262 Free PMC article. Clinical Trial.

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