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Page 1
A non-canonical vitamin K cycle is a potent ferroptosis suppressor.
Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada KI, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourão ASD, Linkermann A, Geissler EK, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt DA, Conrad M. Mishima E, et al. Among authors: proneth b. Nature. 2022 Aug;608(7924):778-783. doi: 10.1038/s41586-022-05022-3. Epub 2022 Aug 3. Nature. 2022. PMID: 35922516 Free PMC article.
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.
Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Rådmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Förster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O'Donnell VB, Kagan VE, Schick JA, Conrad M. Friedmann Angeli JP, et al. Among authors: proneth b. Nat Cell Biol. 2014 Dec;16(12):1180-91. doi: 10.1038/ncb3064. Epub 2014 Nov 17. Nat Cell Biol. 2014. PMID: 25402683 Free PMC article.
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.
Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayır H. Kagan VE, et al. Among authors: proneth b. Nat Chem Biol. 2017 Jan;13(1):81-90. doi: 10.1038/nchembio.2238. Epub 2016 Nov 14. Nat Chem Biol. 2017. PMID: 27842066 Free PMC article.
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.
Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Trümbach D, Mao G, Qu F, Bayir H, Füllekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Angeli JP, Conrad M. Doll S, et al. Among authors: proneth b. Nat Chem Biol. 2017 Jan;13(1):91-98. doi: 10.1038/nchembio.2239. Epub 2016 Nov 14. Nat Chem Biol. 2017. PMID: 27842070 Free PMC article.
Role of GPX4 in ferroptosis and its pharmacological implication.
Seibt TM, Proneth B, Conrad M. Seibt TM, et al. Among authors: proneth b. Free Radic Biol Med. 2019 Mar;133:144-152. doi: 10.1016/j.freeradbiomed.2018.09.014. Epub 2018 Sep 13. Free Radic Biol Med. 2019. PMID: 30219704 Review.
FSP1 is a glutathione-independent ferroptosis suppressor.
Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel CH, Mourão A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O'Donnell V, Proneth B, Popowicz GM, Pratt DA, Angeli JPF, Conrad M. Doll S, et al. Among authors: proneth b. Nature. 2019 Nov;575(7784):693-698. doi: 10.1038/s41586-019-1707-0. Epub 2019 Oct 21. Nature. 2019. PMID: 31634899
Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice.
Sato M, Onuma K, Domon M, Hasegawa S, Suzuki A, Kusumi R, Hino R, Kakihara N, Kanda Y, Osaki M, Hamada J, Bannai S, Feederle R, Buday K, Angeli JPF, Proneth B, Conrad M, Okada F, Sato H. Sato M, et al. Among authors: proneth b. Int J Cancer. 2020 Dec 1;147(11):3224-3235. doi: 10.1002/ijc.33262. Epub 2020 Aug 26. Int J Cancer. 2020. PMID: 32818320
39 results