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Inhibition of the angiotensin II type 2 receptor AT2R is a novel therapeutic strategy for glioblastoma.
Perryman R, Renziehausen A, Shaye H, Kostagianni AD, Tsiailanis AD, Thorne T, Chatziathanasiadou MV, Sivolapenko GB, El Mubarak MA, Han GW, Zarzycka B, Katritch V, Lebon G, Lo Nigro C, Lattanzio L, Morse SV, Choi JJ, O'Neill K, Kanaki Z, Klinakis A, Crook T, Cherezov V, Tzakos AG, Syed N. Perryman R, et al. Among authors: zarzycka b. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2116289119. doi: 10.1073/pnas.2116289119. Epub 2022 Aug 2. Proc Natl Acad Sci U S A. 2022. PMID: 35917342 Free PMC article.
Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor.
Audet M, White KL, Breton B, Zarzycka B, Han GW, Lu Y, Gati C, Batyuk A, Popov P, Velasquez J, Manahan D, Hu H, Weierstall U, Liu W, Shui W, Katritch V, Cherezov V, Hanson MA, Stevens RC. Audet M, et al. Among authors: zarzycka b. Nat Chem Biol. 2019 Jan;15(1):11-17. doi: 10.1038/s41589-018-0160-y. Epub 2018 Dec 3. Nat Chem Biol. 2019. PMID: 30510194 Free PMC article.
O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity.
Levine PM, Balana AT, Sturchler E, Koole C, Noda H, Zarzycka B, Daley EJ, Truong TT, Katritch V, Gardella TJ, Wootten D, Sexton PM, McDonald P, Pratt MR. Levine PM, et al. Among authors: zarzycka b. J Am Chem Soc. 2019 Sep 11;141(36):14210-14219. doi: 10.1021/jacs.9b05365. Epub 2019 Aug 28. J Am Chem Soc. 2019. PMID: 31418572 Free PMC article.
Harnessing Ion-Binding Sites for GPCR Pharmacology.
Zarzycka B, Zaidi SA, Roth BL, Katritch V. Zarzycka B, et al. Pharmacol Rev. 2019 Oct;71(4):571-595. doi: 10.1124/pr.119.017863. Pharmacol Rev. 2019. PMID: 31551350 Free PMC article. Review.
Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance.
Chatzigeorgiou A, Seijkens T, Zarzycka B, Engel D, Poggi M, van den Berg S, van den Berg S, Soehnlein O, Winkels H, Beckers L, Lievens D, Driessen A, Kusters P, Biessen E, Garcia-Martin R, Klotzsche-von Ameln A, Gijbels M, Noelle R, Boon L, Hackeng T, Schulte KM, Xu A, Vriend G, Nabuurs S, Chung KJ, Willems van Dijk K, Rensen PC, Gerdes N, de Winther M, Block NL, Schally AV, Weber C, Bornstein SR, Nicolaes G, Chavakis T, Lutgens E. Chatzigeorgiou A, et al. Among authors: zarzycka b. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2686-91. doi: 10.1073/pnas.1400419111. Epub 2014 Feb 3. Proc Natl Acad Sci U S A. 2014. PMID: 24492375 Free PMC article.
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